CYP2C9 Cancer Research Results

CYP2C9, CYP2C9: Click to Expand ⟱
Source:
Type:
CYP2C9, cytochrome P450 enzyme
– CYP2C9 is involved in the metabolism of a range of xenobiotics, including several anticancer drugs, which can affect drug efficacy and toxicity.
– Although CYP2C9 is not traditionally considered an oncogene or tumor suppressor, its expression and genetic variants can influence patient responses to chemotherapy.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
6137- CHr,    Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters
- in-vitro, NA, NA
CYP2C9↓, OATPs↓, ABCG2↓, BioEnh↝,
7769- IBC,    Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters
- in-vivo, NA, NA
*AntiCan↑, *AntiAg↑, *AntiFungal↑, CYP2C9↓, UGT1A↓, CYP2D6↓, CYP2E1↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP2D6↓, 1,   UGT1A↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CYP2E1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

OATPs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioEnh↝, 1,   CYP2C9↓, 2,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: CYP2C9, CYP2C9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:1130  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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