BACE/β-secretase Cancer Research Results

BACE/β-secretase, β-site APP-cleaving enzyme: Click to Expand ⟱
Source:
Type:
BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.

BACE1 - Beta-Site APP Cleaving Enzyme 1 / β-Secretase 1

Abbreviation: BACE1, β-secretase, β-secretase 1

Type: Aspartyl protease / amyloidogenic APP-processing enzyme

Function: BACE1 is a membrane-associated aspartyl protease that performs the initial β-secretase cleavage of amyloid precursor protein (APP). This cleavage generates soluble APPβ and the membrane-bound C99 fragment, which is subsequently cleaved by γ-secretase to produce amyloid-β peptides including Aβ40 and Aβ42.

Alzheimer's Disease: ↑ Increased BACE1 expression or enzymatic activity promotes amyloidogenic APP processing and increases amyloid-β production. Elevated BACE1 activity has been reported in Alzheimer's disease and contributes to Aβ accumulation, plaque formation, synaptic dysfunction, and disease progression. BACE1 inhibition reduces Aβ production, although clinical BACE1 inhibitors have been limited by adverse effects related to the enzyme's normal physiological functions.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, NA, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
4211- Hup,    Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
- in-vitro, NA, NA
*memory↑, *p‑Akt↑, *BACE/β-secretase↓, *cognitive↑,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE/β-secretase↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF∅, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 3,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   memory↑, 2,  
Total Targets: 15

Scientific Paper Hit Count for: BACE/β-secretase, β-site APP-cleaving enzyme
1 Cichoric acid / Chicoric acid
1 Echinacea
1 Huperzine A/Huperzia serrata
1 Mushroom Lion’s Mane
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:1349  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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