TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
HCC, Hepatocellular Carcinoma: Click to Expand ⟱
Hepatocellular Carcinoma
Scientific Papers found: Click to Expand⟱
5436- AG,    Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice
- in-vivo, HCC, NA
TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,
5363- AV,    Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments
- Study, HCC, NA
AKT1↓, EGFR↓, PI3K↓, Bcl-2↓, TumCG↓, Apoptosis↑,
5548- BBR,    Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway
- in-vitro, HCC, SMMC-7721 cell
TumCG↓, Apoptosis↑, Cyt‑c↑, BAX↑, P53↑, Bcl-2↓, survivin↓,
2756- BetA,    Betulinic acid inhibits growth of hepatoma cells through activating the NCOA4-mediated ferritinophagy pathway
- in-vitro, HCC, HUH7 - in-vitro, HCC, H1299
TumCP↓, ROS↑, antiOx↓, TumCG↓, TumCMig↓, NRF2↓, GPx4↓, HO-1↓, NCOA4↑, FTH1↓, Ferritin↑, Ferroptosis↑, GSH↓, MDA↓,
7976- BUL,    Antitumor activity and toxicity relationship of annonaceous acetogenins
- in-vitro, HCC, H22
toxicity↓, TumCG↓, *toxicity↑, *ROS↑, *Ca+2↑, *BAX↑,
5763- CAPE,    Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
- NA, HCC, NA
*antiOx↑, *neuroP↑, NF-kB↓, TumCG↓, TumMeta↓, MMPs↓, P53↑, ChemoSen↑,
6124- CHr,  EGCG,    The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells
- in-vitro, HCC, HepG2
TumCG↓, Apoptosis↓, GRP78/BiP↑, eff↑, cl‑Casp7↑, cl‑PARP↑, eff↑, UPR↑, ER Stress↑, p‑eIF2α↑, XBP-1↝, Proteasome↓,
1033- CHr,    Chrysin inhibits hepatocellular carcinoma progression through suppressing programmed death ligand 1 expression
- vitro+vivo, HCC, NA
TumCG↓, CD4+↑, CD8+↑, PD-L1↓,
7237- EGb 761,    Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway
- in-vitro, HCC, HepG2
TumCG↓, tumCV↓, Apoptosis↑, P53↑, NF-kB↓,
655- EGCG,    A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- in-vitro, HCC, HepG2
AFP↓, TumAuto↑, LC3II↑, TumCG↓, MMP↓,
1320- EMD,  SRF,    Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7 - vitro+vivo, Hepat, SK-HEP-1
SREBF2↓, Akt↓, TumCCA↑, TumCG↓, STAT3↓,
6427- FEO,    Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
- vitro+vivo, HCC, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCG↓, survivin↓, mtDam↑, Casp3↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
7198- GBE,    Ginkgo biloba extract suppresses hepatocellular carcinoma progression by inhibiting the recruitment of myeloid-derived suppressor cells through reduced CXCL1 secretion via SRC downregulation
- vitro+vivo, HCC, NA
TumCG↓, Src↓, CXCL1↓, Dose↝,
6564- Ger,    Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
- in-vitro, HCC, HepG2
TumCG↓, HMG-CoA↓, TumCP↓, eff↑, Dose↝,
7264- Gink,    Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis
- vitro+vivo, HCC, HepG2 - NA, HCC, SK-HEP-1
tumCV↓, TumCCA↓, Casp3↑, Cyt‑c↑, TumCG↓, Dose↝,
4642- HT,    Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
- in-vitro, HCC, HepG2 - NA, NA, Hep3B - NA, NA, SK-HEP-1
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, TumCG↓, angioG↓,
8179- Las,    Lasiokaurin suppresses hepatocellular carcinoma proliferation and induces apoptosis via the JAK2/STAT3 pathway
- in-vitro, HCC, NA
Apoptosis↑, TumCCA↑, TumCG↓, JAK2↓, STAT3↓,
1196- MAG,    2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression
- in-vitro, HCC, NA
TumCG↓, TumCMig↓, TumCI↓, TumCCA↑, HDAC↓,
2488- metroC,    Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma
- in-vitro, HCC, HUH7 - in-vivo, HCC, NA
TumCG↓, toxicity↓, OS↑, TSP-1↑, Dose↓, Dose↓,
5611- NaHCO3,    NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
- vitro+vivo, HCC, HepG2
tumCV↓, TumCG↓, pH↑, eff↑, Imm↑,
1944- PL,    Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress
- in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2
ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,
4966- PSO,    Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma
- vitro+vivo, HCC, HepG2
Pyro↑, TumCG↓, mt-ROS↑, Casp3↑, cl‑GSDME↑, IL1β↑, IL18↑, NK cell↑,
6808- RF,    Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced hepatocellular carcinoma
- Trial, HCC, NA
OS↑, *toxicity↓, Dose↝, TumCG↓, Dose↝, Dose↝, Dose↝, eff↑,
6807- RF,    Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx
- NA, HCC, NA
TumVol↓, Ca+2↑, TumCG↓, Dose↝,
2357- SK,    GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism
- Study, HCC, NA - in-vivo, NA, NA
AntiTum↑, GTPBP4↓, PKM2↓, lactateProd↓, GlucoseCon↓, Glycolysis↓, E-cadherin↑, TumCG↓,
2485- VitC,  TACE,    High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
- Case Report, HCC, NA
ROS↑, Dose↝, Dose↝, TumCG↓, Remission↑,

Showing Research Papers: 1 to 27 of 27

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Ferroptosis↑, 2,   GPx4↓, 2,   GSH↓, 2,   HO-1↓, 1,   lipid-P↑, 2,   MDA↓, 1,   NRF2↓, 1,   ROS↑, 4,   mt-ROS↑, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↝, 1,   MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   SREBF2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 6,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 4,   Casp3↑, 3,   cl‑Casp3↑, 1,   proCasp3↓, 1,   cl‑Casp7↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 2,   cl‑GSDME↑, 1,   Proteasome↓, 1,   Pyro↑, 1,   survivin↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↝, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 3,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↝, 1,   CycB/CCNB1↝, 1,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GTPBP4↓, 1,   HDAC↓, 1,   PI3K↓, 1,   Src↓, 1,   STAT3↓, 2,   TumCG↓, 27,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMPs↓, 1,   TSP-1↑, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↑, 1,   EGFR↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CXCL1↓, 1,   IL18↑, 1,   IL1β↑, 1,   IL2↑, 1,   IL6↑, 1,   Imm↑, 1,   JAK2↓, 1,   NF-kB↓, 3,   NK cell↑, 1,   PD-L1↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↓, 2,   Dose↝, 10,   eff↓, 1,   eff↑, 5,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   EGFR↓, 1,   Ferritin↑, 1,   IL6↑, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS↑, 2,   Remission↑, 1,   toxicity↓, 3,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 111

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   toxicity↓, 1,   toxicity↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: TumCG, Tumor cell growth
2 Chrysin
2 EGCG (Epigallocatechin Gallate)
2 EMF
1 Astragalus
1 Aloe anthraquinones
1 Berberine
1 Betulinic acid
1 Bullatacin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Ginkgo biloba-EGb 761
1 Emodin
1 Sorafenib (brand name Nexavar)
1 Fennel Oil/Foeniculum vulgare
1 Formononetin
1 Ginkgo biloba
1 Geraniol
1 Ginkgetin
1 HydroxyTyrosol
1 Lasiodin
1 Magnolol
1 metronomic chemo
1 Bicarbonate(Sodium)
1 Piperlongumine
1 Psoralidin
1 Shikonin
1 Vitamin C (Ascorbic Acid)
1 Transarterial Chemoembolization
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:10  Cells:%  prod#:%  Target#:323  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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