miR-34a Cancer Research Results

miR-34a, mir-34 precursor family: Click to Expand ⟱

Source:

Type:

MiR-34a expression levels were correlated with tumor differentiation, lymphatic metastasis, clinical stages, and survival rates.

miR-34a is a well-known molecule transcriptionally induced by p53.

-Low miR-34a expression is common in cancers and is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, ovarian, and glioblastoma.
-High miR-34a expression is often associated with better prognosis and improved overall survival in various cancers.

HCC, Hepatocellular Carcinoma: Click to Expand ⟱

Hepatocellular Carcinoma

Scientific Papers found: Click to Expand⟱

7894-

IVT,

Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression

in-vitro,

HCC,

SK-HEP-1

CD44↓, CSCs↓, ABCG2↓, ALDH1A1↓, Nanog↓, miR-34a↑, BAX↑, Bcl-2↓, Mcl-1↓, Apoptosis↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, Mcl-1↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1, CD44↓, 1, CSCs↓, 1, miR-34a↑, 1, Nanog↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-34a, mir-34 precursor family

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells