RAD51 Cancer Research Results

RAD51, RAD51: Click to Expand ⟱
Source:
Type:
RAD51 is a protein that plays a crucial role in the repair of DNA double-strand breaks through homologous recombination (HR). It is a key component of the DNA repair machinery and is essential for maintaining genome stability.
RAD51 expression has been correlated with other biomarkers of DNA repair and genomic instability, such as BRCA1 and BRCA2.
Overexpression: breast, ovarian, prostate, lung
Underexpression: CRC, pancreatic, Hepatocellular, RCC, Melanoma, Thyroid
Kidney, Kidney (Renal Cell) Cancer: Click to Expand ⟱
Kidney (Renal Cell) Cancer
Scientific Papers found: Click to Expand⟱
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,   RAD51↓, 1,   γH2AX↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RAD51, RAD51
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:12  Cells:%  prod#:%  Target#:666  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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