BMP7/OP1 Cancer Research Results

BMP7/OP1, Bone Morphogenetic Protein 7: Click to Expand ⟱
Source:
Type:

BMP-7 - Bone Morphogenetic Protein 7

Type: TGF-β superfamily growth factor / morphogen

Function: BMP-7 is a secreted signaling protein that binds BMP type I and type II receptors and primarily activates SMAD1/5/8 signaling. It regulates differentiation, proliferation, tissue development, extracellular matrix remodeling, epithelial-mesenchymal plasticity, stem-cell behavior, immune responses, and bone formation.

Cancer: ↕ Context-dependent, with a frequent pro-tumorigenic association. Increased BMP-7 expression or signaling has been associated with tumor progression, metastasis, bone tropism, M2 macrophage polarization, immune suppression, and resistance to anticancer therapy in several cancers. However, BMP-7 can also suppress EMT, induce differentiation or senescence, and inhibit metastatic progression in selected tumor contexts.
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
7570- HYP,    Hyperoside suppresses BMP-7-dependent PI3K/AKT pathway in human hepatocellular carcinoma cells
- in-vitro, Liver, HepG2
TumCCA↑, TumCP↓, BMP7/OP1↓, p‑Akt↓, PI3K↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: BMP7/OP1, Bone Morphogenetic Protein 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:1658  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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