TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1 Cancer Research Results

TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1, - Tumor Necrosis Factor Receptor Superfamily Member 25 / Death Receptor 3: Click to Expand ⟱
Source:
Type:

TNFRSF25 - Tumor Necrosis Factor Receptor Superfamily Member 25 / Death Receptor 3

Abbreviation: TNFRSF25, DR3

Alternative Names: Death Receptor 3, APO-3, LARD, TRAMP, WSL-1, TR3

Type: Tumor necrosis factor receptor superfamily member / death receptor / immune signaling receptor

Function: DR3 is a type I transmembrane receptor containing an intracellular death domain. Its principal ligand is TL1A/TNFSF15. DR3 signaling can recruit adaptor proteins including TRADD and activate caspase-dependent apoptosis, necroptosis, NF-κB, JNK, and immune-cell activation pathways.

Cancer: ↕ Context-dependent. DR3 activation can induce apoptosis or necroptosis in cancer cells and can enhance antitumor immune responses. However, DR3 can also activate NF-κB-dependent survival or inflammatory signaling, and certain splice variants have been associated with invasion and metastasis in selected cancers.

Favorable Direction in Cancer: Context-dependent. ↑ DR3 death-signaling can be favorable where it promotes apoptosis or necroptosis, whereas ↓ DR3 signaling may be favorable in tumors where DR3 promotes survival, inflammation, invasion, or metastasis.

Interpretation Note: Do not confuse DR3/TNFRSF25 with DcR3/TNFRSF6B. DcR3 is a soluble decoy receptor and is a distinct target.
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   WEE1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 1,   Casp10↑, 1,   Casp3↑, 1,   Casp8↑, 1,   DR5↑, 1,   Fas↑, 1,   JNK↑, 1,   PUMA↑, 1,   survivin↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

P70S6K↓, 1,  

Migration(tgid=13) ⓘ

PKCδ↓, 1,   TumCP↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1, - Tumor Necrosis Factor Receptor Superfamily Member 25 / Death Receptor 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:1789  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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