WEE1 Cancer Research Results

WEE1, WEE1 G2 Checkpoint Kinase: Click to Expand ⟱
Source:
Type:

WEE1 - WEE1 G2 Checkpoint Kinase

Abbreviation: WEE1

Type: Protein kinase / cell-cycle checkpoint kinase / DNA-damage response regulator

Function: WEE1 inhibits cyclin-dependent kinases, particularly CDK1 and CDK2, through inhibitory phosphorylation. This restrains S-phase progression and G2/M transition, prevents premature mitotic entry, stabilizes replication forks, and allows time for DNA-damage repair.

Cancer: ↑ WEE1 is frequently overexpressed or functionally relied upon in cancer cells, particularly tumors with defective TP53-dependent G1 checkpoint control. Increased WEE1 activity helps cancer cells tolerate replication stress and DNA damage by delaying cell-cycle progression and permitting repair.

Favorable Direction in Cancer: ↓ WEE1 activity is generally favorable in WEE1-dependent cancers because checkpoint inhibition can increase replication stress, prevent adequate DNA repair, force premature mitotic entry, and promote mitotic catastrophe and cancer-cell death.

Interpretation Note: WEE1 also has normal genome-protective functions in non-cancerous cells. Its cancer-promoting role is therefore best understood as tumor cells exploiting an otherwise protective checkpoint mechanism.
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   WEE1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 1,   Casp10↑, 1,   Casp3↑, 1,   Casp8↑, 1,   DR5↑, 1,   Fas↑, 1,   JNK↑, 1,   PUMA↑, 1,   survivin↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

P70S6K↓, 1,  

Migration(tgid=13) ⓘ

PKCδ↓, 1,   TumCP↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: WEE1, WEE1 G2 Checkpoint Kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:1790  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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