eff Cancer Research Results

eff, efficacy: Click to Expand ⟱
Source:
Type:
Power to enhance an anti cancer effect
Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
2835- AgNPs,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
1539- Api,  LT,    Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells
- in-vitro, Liver, HepG2
SREBP2↓, eff↑, p‑MEK↓, p‑ERK↓,
1558- Api,    Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique
- in-vitro, Liver, HepG2
BioAv↑, *toxicity∅, eff↑,
2578- ART/DHA,  RES,    Synergic effects of artemisinin and resveratrol in cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
Dose↝, TumCMig↓, Apoptosis↑, necrosis↑, ROS↑, eff↑,
2022- BBR,  GoldNP,  Rad,    Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
- in-vitro, Liver, SMMC-7721 cell - in-vitro, Nor, HL7702
*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,
5513- bemA,    ACLY inhibition promotes tumour immunity and suppresses liver cancer
- in-vitro, Liver, NA
ACLY↓, AMPK↑, eff↑, other↝, eff↝,
5867- CA,    Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines
- in-vitro, Pca, DU145 - in-vitro, Liver, Hep3B - in-vitro, AML, K562 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCP↓, eff↑, other↝,
7168- CHA,    The anticancer effect of chaetocin is enhanced by inhibition of autophagy
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HepG3 - in-vitro, Liver, HUH7
Apoptosis↓, TumAuto↑, ROS↑, Hif1a↓, SUV39H↓, cl‑PARP↑, eff↑, eff↑,
1602- Cu,    A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1 - in-vitro, Lung, A549 - in-vitro, Liver, HepG2
eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,
5386- docx,  AsP,    Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
- vitro+vivo, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Pca, PC3
Dose↝, ROS↑, eff↑, eff↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
3241- EGCG,    Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, eff↑,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7882- isoO,    Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair
- in-vitro, Liver, NA
TumCP↓, ATM↓, eff↑,
1946- PL,  PI,    Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling
- in-vitro, Liver, NA
eff↑, toxicity↓, TrxR↓, ROS↑, MMP↓, p38↑, Akt↓, mTOR↓,
6811- RF,    Continuous Exposure to 1.7 GHz LTE Electromagnetic Fields Increases Intracellular Reactive Oxygen Species to Decrease Human Cell Proliferation and Induce Senescence
- in-vitro, Liver, HUH7 - in-vitro, Liver, Hep3B - in-vitro, Cerv, HeLa - in-vitro, neuroblastoma, SH-SY5Y - in-vitro, Nor, IMR90
TumCP↓, eff↑, ROS↑, eff↓,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
4470- SeNPs,  Chit,    Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan
- in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
Dose↝, AntiCan↑, eff↑,
4471- SeNPs,    Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis
- in-vitro, Liver, HepG2
eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,
1459- SFN,  AF,    Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,
5106- SSE,  GSH,    Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells
- in-vitro, Liver, HepG2
ROS↑, Apoptosis↑, eff↑, GSH↓,

Showing Research Papers: 1 to 23 of 23

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 23

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   H2O2↑, 1,   c-Iron↑, 1,   lipid-P↑, 1,   ROS↑, 14,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   p‑MEK↓, 1,   MMP↓, 4,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 1,   AMPK↑, 1,   LDH↓, 1,   lipoGen↓, 1,   PDK1 / PDPK1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↓, 1,   Apoptosis↑, 8,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-2↑, 1,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp↑, 3,   Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   JNK↑, 1,   necrosis↑, 1,   p38↑, 2,   Proteasome↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   DNAdam↑, 2,   cl‑PARP↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   mTOR↓, 2,   mTOR⇅, 1,   NOTCH1↓, 1,   PI3K↓, 2,   PTEN↑, 1,   p‑STAT3↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,   TSC1↑, 1,   TumCMig↓, 1,   TumCP↓, 6,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   IL12↑, 1,   IL2↑, 1,   Imm↑, 1,   JAK2↓, 1,   PD-L1↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 3,   Dose?, 1,   Dose↝, 4,   Dose∅, 1,   eff↓, 3,   eff↑, 29,   eff↝, 4,   MDR1↓, 1,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   E6↓, 1,   E7↓, 1,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 2,   QoL↑, 1,   radioP↑, 1,   toxicity↓, 1,  
Total Targets: 105

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GSH↑, 1,   SOD↑, 1,   VitC↑, 1,   VitE↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioEnh↑, 1,   Half-Life∅, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity?, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 13

Scientific Paper Hit Count for: eff, efficacy
2 Apigenin (mainly Parsley)
2 chitosan
2 Selenium NanoParticles
1 Astragalus
1 Silver-NanoParticles
1 Glucose
1 Luteolin
1 Artemisinin
1 Resveratrol
1 Berberine
1 Gold NanoParticles
1 Radiotherapy/Radiation
1 bempedoic acid
1 Carnosic acid
1 chaetocin
1 Copper and Cu NanoParticles
1 Docetaxel
1 Ascorbyl Palmitate
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Gambogic Acid
1 verapamil
1 Ginger/6-Shogaol/Gingerol
1 isoorientin
1 Piperlongumine
1 Piperine
1 EMF
1 Selenium
1 polyethylene glycol
1 Sulforaphane (mainly Broccoli)
1 Auranofin
1 Selenite (Sodium)
1 Glutathione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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