Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Liver, Liver Cancer: Click to Expand ⟱
Liver Cancer
Scientific Papers found: Click to Expand⟱
7873- isoO,    Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
- in-vitro, Liver, HepG2 - in-vitro, CRC, HT-29 - in-vitro, Lung, A549
ChemoSen↑, TumCP↓, chemoP↑, *ROS↓, *mtDam↓, *Apoptosis↓, *cardioP↑, *NRF2↑, *TGF-β↑, *p‑JNK↓, *p‑p38↓, *MAPK↝, *Akt↝, *STAT3↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↝, 1,   Apoptosis↓, 1,   p‑JNK↓, 1,   MAPK↝, 1,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↝, 1,  

Migration(tgid=13) ⓘ

TGF-β↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:14  Cells:%  prod#:%  Target#:4  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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