SIRT6 Cancer Research Results

SIRT6, Sirtuin 6: Click to Expand ⟱
Source:
Type:
– SIRT6 is involved in maintaining genomic stability through its roles in DNA repair and chromatin remodeling.
– By promoting efficient DNA repair, SIRT6 may help prevent the accumulation of genetic mutations that drive tumorigenesis.

– In several studies, lower SIRT6 expression has been associated with more aggressive tumor behavior and poorer overall survival, supporting its role as a tumor suppressor in those contexts.
– Conversely, in some cancers, higher SIRT6 expression has been linked to enhanced survival signaling or metabolic reprogramming that might support tumor growth, suggesting a possible oncogenic role.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   i-Iron↑, 1,   i-MDA↑, 1,   NRF2↓, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

SIRT6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

i-ROS↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: SIRT6, Sirtuin 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1135  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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