MIP‑1α/CCL3 Cancer Research Results

MIP‑1α/CCL3, C-C Motif Chemokine Ligand 3: Click to Expand ⟱
Source:
Type:
CCL3 (Macrophage Inflammatory Protein-1α, MIP‑1α)

-CCL3 acts as a chemoattractant for various immune cells including NK cells, dendritic cells, and monocytes.

– Its role in tumors can be dual: promoting anti-tumor responses in some contexts while in others, especially through chronic inflammation, it may participate in tumor progression.

CCL3 - C-C Motif Chemokine Ligand 3

Abbreviation: CCL3, MIP-1α

Type: Chemokine / inflammatory cytokine

Function: CCL3 is a CC-family chemokine that signals primarily through CCR1 and CCR5 and regulates recruitment and activation of monocytes, macrophages, lymphocytes, and other immune cells. It plays important roles in inflammatory responses, immune-cell trafficking, and tumor-microenvironment signaling.

Cancer: ↕ Context-dependent. CCL3 can support antitumor immune-cell recruitment in some settings, but elevated CCL3 frequently promotes a pro-inflammatory tumor microenvironment, recruitment of tumor-supportive myeloid cells, angiogenesis, invasion, metastasis, and treatment resistance.

Alzheimer's Disease: ↑ Increased CCL3 is associated with neuroinflammation and activation or recruitment of microglia and other immune cells in Alzheimer's disease and related neurodegenerative models.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
7325- GSE,    The Effects of a Grape Seed Procyanidin Extract on Cytochrome P450 3A4 Activity and Inflammatory Mediators in the Lungs of Heavy Active and Former Smokers
- in-vitro, Lung, NA
*cardioP↑, *Inflam↓, BioAv↑, TNF-α↓, MIP‑1α/CCL3↓, GranB/GZMB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

GranB/GZMB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

MIP‑1α/CCL3↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: MIP‑1α/CCL3, C-C Motif Chemokine Ligand 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:1275  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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