PDK1 / PDPK1 Cancer Research Results

PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱
Source:
Type:

PDPK1 - 3-Phosphoinositide-Dependent Protein Kinase 1

Abbreviation: PDPK1, PDK1

Type: Serine/threonine protein kinase / PI3K pathway signaling kinase / AGC kinase activator

Function: PDPK1 is a central signaling kinase downstream of phosphoinositide 3-kinase. It phosphorylates and activates multiple AGC-family kinases, including AKT, S6K, SGK, RSK, and selected PKC isoforms, thereby regulating proliferation, survival, metabolism, migration, and cellular growth.

Cancer: ↑ Frequently overexpressed, hyperactivated, or functionally dysregulated in cancer. Increased PDPK1 signaling enhances PI3K-AKT pathway output, proliferation, survival, migration, invasion, metastasis, metabolic adaptation, and resistance to anticancer therapies. Genetic or pharmacological suppression of PDPK1 can inhibit tumor growth and restore treatment sensitivity in experimental models.

Favorable Direction in Cancer: ↓ PDPK1 expression or kinase activity is generally favorable.
Lung, Lung Cancer: Click to Expand ⟱
Lung CSC (Cancer Stem Cells) markers (CD133, CD44, ALDHA1, Nanog and Oct4)
Scientific Papers found: Click to Expand⟱
267- ALA,    α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
Apoptosis↑, ROS↑, PDK1 / PDPK1↓, NRF2↓, PDK1 / PDPK1↓, Bcl-2↓, Casp9↑, Dose∅,
999- Ba,    Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
- in-vitro, Lung, H460
TumCP↓, p‑PDK1 / PDPK1↓, p‑Akt↓, EMT↓, E-cadherin↑, Vim↓,
2473- BA,    Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H460
EMT↓, PDK1 / PDPK1↓, Akt↓, TumCMig↓, E-cadherin↑, Vim↓,
2702- BBR,    The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1 / PDPK1↓, DNMT1↓, eff↑,
1259- CAP,    Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H2009
Hif1a↓, PDK1 / PDPK1↓, GLUT1↓, ROS↑, mitResp↓, ATP↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
7287- GGB,  Rad,    Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, TumCMig↓, RadioS↑, TumCCA↑, PI3K↓, p‑Akt↓, PDK1 / PDPK1↓,
8213- LCA,    Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells
- in-vitro, CRC, HCT116 - in-vitro, Lung, H1299 - in-vitro, Lung, H322
Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, ROS↑, mitResp↓, ATP↓, tumCV?,
2469- SK,    Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2
- in-vitro, Lung, H1975
Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, GSDME↑, ROS↑, COX2/PTGS2↓, PDK1 / PDPK1↓, Akt↓, ERK↓, eff↓, eff↓, eff↑,
2470- SK,    PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism
- in-vitro, Lung, H1299
PKM2↓, PDK1 / PDPK1↓, Glycolysis↓,
1003- SSE,    Sodium selenite inhibits proliferation of lung cancer cells by inhibiting NF-κB nuclear translocation and down-regulating PDK1 expression which is a key enzyme in energy metabolism expression
- vitro+vivo, Lung, NA
NF-kB↓, PDK1 / PDPK1↓, p‑p65↑, p‑IκB↑, BAX↑, lactateProd↓, MMP↓, Cyt‑c↑, mitResp↑, Apoptosis↑,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mitResp↓, 2,   mitResp↑, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   lactateProd↓, 1,   PDK1 / PDPK1↓, 11,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 2,   Apoptosis↑, 4,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 2,   Casp9↑, 1,   Cyt‑c↑, 1,   GSDME↑, 1,   MAPK↓, 1,   Pyro↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV?, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   ERK↓, 1,   FOXO3↑, 1,   mTOR⇅, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 2,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 3,   Vim↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   p‑IκB↑, 1,   NF-kB↓, 1,   p‑p65↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose∅, 2,   eff↓, 2,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,  
Total Targets: 54

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  
Total Targets: 4

Scientific Paper Hit Count for: PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1
2 Shikonin
1 Alpha-Lipoic-Acid
1 Baicalein
1 Baicalin
1 Berberine
1 Capsaicin
1 Ellagic acid
1 Ginkgolide B
1 Radiotherapy/Radiation
1 Licochalcone A
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:15  Cells:%  prod#:%  Target#:246  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page