Shh Cancer Research Results

Shh, sonic hedgehog: Click to Expand ⟱
Source:
Type: Hedgehog
Components of Shh pathway (smoothened, patched, Gli1 and Gli2).
Sonic Hedgehog (SHH) is a key signaling protein involved in various developmental processes, including cell growth, differentiation, and tissue patterning. The SHH signaling pathway is crucial during embryonic development, but its dysregulation can lead to several types of cancer.
The SHH pathway is activated when the SHH protein binds to its receptor, Patched (PTCH). This interaction relieves the inhibition of another protein, Smoothened (SMO), leading to the activation of downstream signaling that promotes cell proliferation and survival.

In many cancers, SHH and its downstream signaling components are often overexpressed. This overexpression can lead to increased cell proliferation, survival, and tumor growth.
MB, Medulloblastoma: Click to Expand ⟱
Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults.
Activation of these three pathways Akt/NF-kB, Shh, and Wnt/b-catenin converge in the upregulation of C-myc, N-myc, and Cyclin D1, three oncoproteins that play key roles in the development of medulloblastomas. High levels of these three oncoproteins were considered to be bad prognosis because they are related to unfavorable therapeutic outcome.
Scientific Papers found: Click to Expand⟱
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓, Apoptosis↑, ChemoSen↑, RadioS↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   n-MYC↓, 1,   PTCH1↓, 1,   Shh↓, 1,  

Migration ⓘ

β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,   RadioS↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Shh, sonic hedgehog
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:16  Cells:%  prod#:%  Target#:282  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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