Database Query Results : , ,

MB, Medulloblastoma: Click to Expand ⟱
Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults.
Activation of these three pathways Akt/NF-kB, Shh, and Wnt/b-catenin converge in the upregulation of C-myc, N-myc, and Cyclin D1, three oncoproteins that play key roles in the development of medulloblastomas. High levels of these three oncoproteins were considered to be bad prognosis because they are related to unfavorable therapeutic outcome.
Scientific Papers found: Click to Expand⟱
7- BBR,    Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
- vitro+vivo, MB, NA
HH↓, Gli1↓, PTCH1↓, Smo↓,
18- CBC/D,    Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli
- vitro+vivo, MB, NA
HH↓, Gli1↓,
12- CUR,    Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
- in-vitro, MB, DAOY
HH↓, Shh↓, Gli1↓, PTCH1↓, cMyc↓, n-MYC↓, cycD1/CCND1↓, Bcl-2↓, NF-kB↓, Akt↓, β-catenin/ZEB1↓, survivin↓,
32- GlaB,    Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- in-vivo, MB, NA
HH↓, Gli1↓, PTCH1↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,
1737- MFrot,  Fe,  MF,    Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells
- in-vitro, MB, A375
Dose∅, tumCV↓,
107- SS,    Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
- vitro+vivo, MB, NA
HH↓, Smo↓, Gli↓, Gli1↓, PTCH1↓,
1756- WBV,    Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
- in-vitro, MB, A431
Apoptosis↑, GlucoseCon↝, other↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ATG7↑, 1,   cMyc↓, 1,   GlucoseCon↝, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli↓, 1,   Gli1↓, 5,   HH↓, 5,   n-MYC↓, 1,   PTCH1↓, 4,   Shh↓, 1,   Smo↓, 2,  

Migration ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   ChemoSen↑, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:16  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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