Shh Cancer Research Results

Shh, sonic hedgehog: Click to Expand ⟱
Source:
Type: Hedgehog
Components of Shh pathway (smoothened, patched, Gli1 and Gli2).
Sonic Hedgehog (SHH) is a key signaling protein involved in various developmental processes, including cell growth, differentiation, and tissue patterning. The SHH signaling pathway is crucial during embryonic development, but its dysregulation can lead to several types of cancer.
The SHH pathway is activated when the SHH protein binds to its receptor, Patched (PTCH). This interaction relieves the inhibition of another protein, Smoothened (SMO), leading to the activation of downstream signaling that promotes cell proliferation and survival.

In many cancers, SHH and its downstream signaling components are often overexpressed. This overexpression can lead to increased cell proliferation, survival, and tumor growth.
MG, Malignant Gliomas: Click to Expand ⟱
Malignant Gliomas: more and more evidences indicate that it is associated with multistep process involving accumulation of aberrant activation in signaling pathways such as AKT, NF‐kB, ERK, mTOR, JAK/STAT3, and SHH/GLI1.
Scientific Papers found: Click to Expand⟱
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXM1↓, 1,   Gli1↓, 1,   HH↓, 1,   Shh↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Clinical Biomarkers ⓘ

FOXM1↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Shh, sonic hedgehog
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:17  Cells:%  prod#:%  Target#:282  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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