FOXM1 Cancer Research Results

FOXM1, FOXM1 transcription factor: Click to Expand ⟱
Source:
Type:
FOXM1 transcription factor is a regulator of a broad range of biological processes.
Master Driver of Proliferation, Genomic Instability, and Therapy Resistance
Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. FOXM1 is repeatedly overexpressed in a variety of human cancers.
High FOXM1 expression is associated with aggressive tumor characteristics and poor overall survival. FOXM1 is generally considered a marker of poor prognosis across various cancer types.
FOXM1 is used as a clinical biomarker for Epigentic instability


MG, Malignant Gliomas: Click to Expand ⟱
Malignant Gliomas: more and more evidences indicate that it is associated with multistep process involving accumulation of aberrant activation in signaling pathways such as AKT, NF‐kB, ERK, mTOR, JAK/STAT3, and SHH/GLI1.
Scientific Papers found: Click to Expand⟱
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXM1↓, 1,   Gli1↓, 1,   HH↓, 1,   Shh↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Clinical Biomarkers ⓘ

FOXM1↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FOXM1, FOXM1 transcription factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:17  Cells:%  prod#:%  Target#:351  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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