ATM Cancer Research Results

ATM, similar to Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated); ataxia telangiectasia mutated: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

ATM is considered a moderate cancer risk gene. A mutation in a moderate risk gene is just one risk factor that can contribute to cancer development. ATM has traditionally been assigned the role of a tumor suppressor. However, in both humans and mice, lymphoma and leukemia are the only clear-cut examples of cancer development caused by ATM deficiency(13). Its roles in other types of cancer, especially solid tumors, are much less clear.
ATM, a master regulator of DNA damage response.

NMSC, Non Melanoma Skin Cancer: Click to Expand ⟱

Non Melanoma Skin Cancer

Scientific Papers found: Click to Expand⟱

487-

MF,

Extremely Low-Frequency Electromagnetic Fields Cause G1 Phase Arrest through the Activation of the ATM-Chk2-p21 Pathway

in-vitro,

NMSC,

HaCaT

60 Hz, 1.5 mT for 144 h

ATM↑, Chk2↑, P21↑, TumCCA↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Chk2↑, 1,

DNA Damage & Repair ⓘ

ATM↑, 1,

Cell Cycle & Senescence ⓘ

P21↑, 1, TumCCA↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: ATM, similar to Serine-protein kinase ATM (Ataxia telangiectasia mutated) (A-T, mutated); ataxia telangiectasia mutated

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells