CDC2 Cancer Research Results

CDC2, cell division cycle 2: Click to Expand ⟱
Source:
Type:
CDC2 is a gene that encodes a protein known as cyclin-dependent kinase 1 (CDK1), a critical regulator of the cell cycle. CDK1 (historically referred to as CDC2 in some contexts) plays a central role in controlling the transition from the G₂ phase to mitosis (M phase).
NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
Scientific Papers found: Click to Expand⟱
5720- BF,    Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
- in-vitro, NSCLC, NA
STAT3↓, CycB/CCNB1↓, CDC2↓, Mcl-1↓, survivin↓, VEGF↓, Bcl-2↓, BAX↑, Casp3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

CycB/CCNB1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDC2, cell division cycle 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:19  Cells:%  prod#:%  Target#:1323  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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