HIF-1 Cancer Research Results

HIF-1, HIF-1 signaling: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays a crucial role in cellular responses to low oxygen levels (hypoxia). It is composed of two subunits: HIF-1α and HIF-1β. Under normal oxygen conditions, HIF-1α is rapidly degraded, but in hypoxic conditions, it stabilizes, translocates to the nucleus, and dimerizes with HIF-1β to activate the transcription of various genes involved in processes such as angiogenesis, metabolism, and cell survival.
HIF-1α is often overexpressed due to the hypoxic microenvironment created by rapid tumor growth and inadequate blood supply. This upregulation allows cancer cells to adapt to low oxygen levels. HIF-1 regulates the expression of numerous target genes involved in angiogenesis (e.g., VEGF), glucose metabolism (e.g., GLUT1), cell survival, and invasion. The activation of these genes promotes tumor growth and metastasis.
However, HIF-1 is expressed in pathological conditions such as cancer and obesity.
NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
Scientific Papers found: Click to Expand⟱
257- AL,  Cisplatin,    Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors
- in-vitro, NSCLC, A549
ROS↑, HIF-1↓, E-cadherin↑, N-cadherin↓, antiOx↓, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   ROS↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,  

Angiogenesis & Vasculature ⓘ

HIF-1↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HIF-1, HIF-1 signaling
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:19  Cells:%  prod#:%  Target#:142  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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