HER2/EBBR2 Cancer Research Results
HER2/EBBR2, Human epidermal growth factor receptor 2: Click to Expand ⟱
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Also called erbB-2 (or ERb-2) -Receptor tyrosine-protein kinase
HER2 is a protein that helps breast cancer cells grow quickly.
HER2/neu protein is a receptor tyrosine kinase that is normally involved in cell growth and division. However, in some cancers, the HER2/neu gene is overexpressed or mutated, leading to an overproduction of the protein. This can cause cells to grow and divide uncontrollably, leading to tumor formation.
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NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
NSCLC, |
A549 |
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in-vitro, |
NSCLC, |
H460 |
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CSCs↓, CD133↓, OCT4↓, β-catenin/ZEB1↓, HER2/EBBR2↓, TumCP↓, PI3K↓, Akt↓, ALDH1A1↓, eff↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Akt↓, 1,
Kinase & Signal Transduction ⓘ
HER2/EBBR2↓, 1,
Proliferation, Differentiation & Cell State ⓘ
ALDH1A1↓, 1, CD133↓, 1, CSCs↓, 1, OCT4↓, 1, PI3K↓, 1,
Migration ⓘ
TumCP↓, 1, β-catenin/ZEB1↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1,
Clinical Biomarkers ⓘ
HER2/EBBR2↓, 1,
Total Targets: 11
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: HER2/EBBR2, Human epidermal growth factor receptor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:19 Cells:% prod#:% Target#:359 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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