TRAILR Cancer Research Results

TRAILR, tumor necrosis factor-related apoptosis-inducing ligand receptor: Click to Expand ⟱

Source:

Type:

TRAILR refers to TRAIL receptors, which are part of the signaling pathway activated by TNF-related apoptosis-inducing ligand (TRAIL). There are several TRAIL receptors, primarily classified into two categories: death receptors and decoy receptors.
Types of TRAIL Receptors
Death Receptors:
TRAIL-R1 (also known as DR4): This receptor can initiate apoptosis when bound by TRAIL. It contains a death domain that activates downstream signaling pathways leading to cell death.
TRAIL-R2 (also known as DR5): Similar to TRAIL-R1, TRAIL-R2 can also trigger apoptosis upon TRAIL binding. It is often considered more potent in inducing apoptosis compared to TRAIL-R1.
Decoy Receptors:
TRAIL-R3 (also known as DcR1): This receptor does not contain a death domain and cannot initiate apoptosis. Instead, it acts as a decoy, binding TRAIL and preventing it from activating the death receptors.
TRAIL-R4 (also known as DcR2): Like TRAIL-R3, TRAIL-R4 also lacks a death domain and serves as a decoy receptor, inhibiting TRAIL-induced apoptosis.

NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱

Non-small Cell Lung Cancer

Scientific Papers found: Click to Expand⟱

48-

QC,

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

in-vitro,

NSCLC,

H460

TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Casp10↑, 1, Fas↑, 1, TNFR 1↑, 1, TRAILR↑, 1,

DNA Damage & Repair ⓘ

DFF45↑, 1,

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1, NF-kB↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TRAILR, tumor necrosis factor-related apoptosis-inducing ligand receptor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells