Casp10 Cancer Research Results

Casp10, cysteine-aspartic protease 10: Click to Expand ⟱

Source:

Type:

Caspase-10 is a member of the caspase family of cysteine proteases, which play essential roles in programmed cell death (apoptosis) and inflammation.
Caspase-10 is crucial for the induction of apoptosis in response to various signals. In many cancers, the apoptotic pathways are dysregulated, allowing cancer cells to evade programmed cell death. Loss of caspase-10 function or expression can contribute to this evasion, promoting tumor survival and growth.
Caspase-10 may act as a tumor suppressor. Its expression can be downregulated in various cancers, including breast, colorectal, and prostate cancers.
Caspase-10 is frequently downregulated in various cancers, which may contribute to the evasion of apoptosis and tumor progression.

NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱

Non-small Cell Lung Cancer

Scientific Papers found: Click to Expand⟱

48-

QC,

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

in-vitro,

NSCLC,

H460

TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Casp10↑, 1, Fas↑, 1, TNFR 1↑, 1, TRAILR↑, 1,

DNA Damage & Repair ⓘ

DFF45↑, 1,

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1, NF-kB↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Casp10, cysteine-aspartic protease 10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells