Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱
Source:
Type:
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.
NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
Scientific Papers found: Click to Expand⟱
7554- HYP,    Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism
- in-vitro, NSCLC, A549
tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,
8152- lamb,  TRAIL/rTRAIL,    Lambertianic Acid Sensitizes Non-Small Cell Lung Cancers to TRAIL-Induced Apoptosis via Inhibition of XIAP/NF-κB and Activation of Caspases and Death Receptor 4
- in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
TumCD↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, cFLIP↓, XIAP↓, BID↑, DR4↑, p‑NF-kB↓, p‑IκB↓,
6431- T4O,    Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo
- vitro+vivo, NSCLC, A549
TumCCA↑, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, Bax:Bcl2↑, XIAP↓, survivin↓, Dose↝, Apoptosis↑, tumCV↓, Cyt‑c↑, eff↑, necrosis↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 2,   XIAP↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   BID↑, 1,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 2,   DR4↑, 1,   JNK↑, 1,   p‑MAPK↑, 1,   necrosis↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

p‑IκB↓, 1,   p‑NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Casp9, Caspase-9
1 Hyperoside
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Terpinen-4-ol / Tea Tree Oil
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:19  Cells:%  prod#:%  Target#:45  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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