NOXA Cancer Research Results
NOXA, Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1): Click to Expand ⟱
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NOXA is a pro-apoptotic protein that plays a crucial role in the regulation of apoptosis, or programmed cell death, in cancer cells. NOXA is a member of the BCL-2 family of proteins, which are key regulators of apoptosis.
Low NOXA expression has been associated with poor prognosis and reduced overall survival.
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NSCLC, Non-small Cell Lung Cancer: Click to Expand ⟱
Non-small Cell Lung Cancer
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
NSCLC, |
A549 |
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in-vitro, |
NSCLC, |
H460 |
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TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ATF3↑, 1, ROS↑, 1,
Mitochondria & Bioenergetics ⓘ
MMP↓, 1,
Cell Death ⓘ
Cyt‑c↑, 1, NOXA↑, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, ER Stress↑, 1, GRP78/BiP↑, 1, IRE1↑, 1,
DNA Damage & Repair ⓘ
P53↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Immune & Inflammatory Signaling ⓘ
IKKα↑, 1,
Drug Metabolism & Resistance ⓘ
eff↝, 1, selectivity↑, 2,
Total Targets: 14
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: NOXA, Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:19 Cells:% prod#:% Target#:874 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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