FLT3 Cancer Research Results

FLT3, fms-related tyrosine kinase 3: Click to Expand ⟱

Source: CGL-Driver Genes

Type: Oncogene

FMS-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that plays a significant role in hematopoiesis and is primarily expressed in hematopoietic stem cells and progenitor cells. It is particularly important in the context of acute myeloid leukemia (AML), where mutations in the FLT3 gene are among the most common genetic alterations.
FLT3 inhibitors, such as midostaurin, gilteritinib, and quizartinib, have been developed to specifically target and inhibit the activity of the mutated FLT3 receptor.

AML, Acute Myeloid Leukemia: Click to Expand ⟱

Acute Myeloid Leukemia

Scientific Papers found: Click to Expand⟱

2212-

SK,

Shikonin Exerts an Antileukemia Effect against FLT3-ITD Mutated Acute Myeloid Leukemia Cells via Targeting FLT3 and Its Downstream Pathways

in-vitro,

AML,

FLT3↓, NF-kB↓, miR-155↓, Diff↑, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1, FLT3↓, 1, TumCG↓, 1,

Migration ⓘ

miR-155↓, 1,

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FLT3, fms-related tyrosine kinase 3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells