UHRF1 Cancer Research Results
UHRF1, Ubiquitin-like with PHD and RING Finger domains 1: Click to Expand ⟱
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UHRF1 (Ubiquitin-like with PHD and RING Finger domains 1) is an epigenetic regulator known to be overexpressed in several cancer types. Its altered expression is often associated with poor prognosis.
-UHRF1 is critical for the maintenance of DNA methylation during replication by recruiting DNA methyltransferase 1 (DNMT1) to hemimethylated DNA.
-Evidence suggests that UHRF1 can negatively regulate p53, a key tumor suppressor protein.
-Several studies have linked high UHRF1 expression with the activation of the PI3K/AKT pathway.
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AML, Acute Myeloid Leukemia: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
BC, |
MDA-MB-468 |
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in-vitro, |
AML, |
JK |
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UHRF1↓, DNMT1↓, DNMT3A↓, DNMTs↓, HDAC1↓, HDAC4↓, HDAC↓, DLC1↑, PPARγ↑, FOXO↑, TET2↑, CYP1B1↑, G9a↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
PPARγ↑, 1,
DNA Damage & Repair ⓘ
CYP1B1↑, 1, DNMT1↓, 1, DNMT3A↓, 1, DNMTs↓, 1, G9a↓, 1, UHRF1↓, 1,
Proliferation, Differentiation & Cell State ⓘ
FOXO↑, 1, HDAC↓, 1, HDAC1↓, 1, HDAC4↓, 1,
Migration ⓘ
DLC1↑, 1,
Drug Metabolism & Resistance ⓘ
TET2↑, 1,
Total Targets: 13
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: UHRF1, Ubiquitin-like with PHD and RING Finger domains 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:2 Cells:% prod#:% Target#:1250 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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