Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
5341- Ajoene,    Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy
- Review, AML, NA
eff↑, AntiThr↑, Bacteria↓, LDH↓, TumCP↓, TumCCA↑, Bcl-2↓, Cyt‑c↑, Casp3↑,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1 / PDPK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1/ATG6↓, ATG3↓, PI3K↓, Akt↓, eff↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6585- EU,    Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
- vitro+vivo, AML, K562
Dose↝, TumCG↓, Apoptosis↑, TumCCA↑, DNAdam↑, Akt↓, Bcl-2↓, PCNA↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
7351- HibSad,    Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression
- in-vitro, AML, HL-60
tumCV↓, DNAdam↑, RB1↓, Bcl-2↓, BAX↑,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
7772- IBC,    Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation
- vitro+vivo, AML, NA
Apoptosis↑, Diff↑, tumCV↓, TumCP↓, MMP↓, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, p‑MEK↑, p‑ERK↑, ROS↑, eff↓,
8259- LCA,    Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid
- in-vitro, BC, MCF7 - in-vitro, AML, HL-60
ChemoSen↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, Bax:Bcl2↑,
42- QC,    Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells
- in-vitro, AML, HL-60
Bcl-2↓, BAX↑, Casp3↑, COX2/PTGS2↓,
1315- SFN,    Bcl-2_and_Caspase-3">Sulforaphane Induces Apoptosis of Acute Human Leukemia Cells Through Modulation of Bax, Bcl-2 and Caspase-3
- in-vitro, AML, K562
TumCP↓, BAX↑, Casp3↑, Bcl-2↓,
1467- SFN,    Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
- in-vitro, AML, U937
Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,
2109- TQ,    Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
- in-vitro, AML, CEM
Apoptosis↓, Bcl-2↓, BAX↑, ROS↑, HSP70/HSPA5↑, Casp3↑, Casp8↑,
7919- VT,    Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway
- in-vitro, AML, U937
TumCD↑, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, chemoPv↑,

Showing Research Papers: 1 to 18 of 18

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑MEK↑, 1,   MMP↓, 4,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   LDH↓, 1,   PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 4,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 10,   mt-Apoptosis↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 1,   Bcl-2↓, 17,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 4,   Casp↑, 1,   Casp3↑, 8,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   proCasp9↑, 1,   Cyt‑c↑, 3,   Fas↑, 1,   IAP1↓, 1,   JNK↑, 1,   Mcl-1↓, 2,   Myc↓, 2,   NOXA↑, 1,   p27/CDKN1B↑, 1,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   DNAdam↑, 5,   P53↓, 1,   P53↑, 2,   PARP↓, 1,   cl‑PARP↑, 5,   PARP1↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Diff↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 1,   mTOR↓, 2,   PI3K↓, 2,   STAT3↓, 2,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

FAK↓, 1,   MMPs↓, 1,   TumCP↓, 6,   TumMeta↓, 1,   TXNIP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Imm↑, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 2,   eff↓, 2,   eff↑, 5,   eff↝, 1,   Half-Life↓, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,   Myc↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoPv↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 90

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
2 Indole-3-carbinol
2 Sulforaphane (mainly Broccoli)
1 Ajoene (compound of Garlic)
1 Apigenin (mainly Parsley)
1 Biochanin A
1 Capsaicin
1 Dichloroacetophenone(2,2-)
1 Dandelion Root
1 Eurycomanone
1 Garcinol
1 Curcumin
1 Hibiscus sabdariffa
1 Isobavachalcone
1 Licochalcone A
1 Quercetin
1 Thymoquinone
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:27  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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