Raf Cancer Research Results

Raf, RAF kinases: Click to Expand ⟱
Source:
Type:
RAF kinases (ARAF, BRAF and CRAF (also known as RAF1) constitute core components of the RAS-RAF-MEK-ERK signalling cascade (ERK signalling), a pathway that mediates signals from cell surface receptors to the nucleus to regulate cell growth, differentiation and survival.
The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives tumour progression and drug resistance in many types of cancer.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7908- VT,    Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway
- in-vitro, AML, NA
MMP↓, DNAdam↑, BCR↓, ABL1↓, HRAS↓, NRAS↓, KRAS↓, Raf↓, p38↑, BAX↑, Casp9↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   BCR↓, 1,   MMP↓, 1,   Raf↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Casp9↑, 1,   p38↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HRAS↓, 1,   NRAS↓, 1,  

Migration(tgid=13) ⓘ

KRAS↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

KRAS↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Raf, RAF kinases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:480  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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