LC3I Cancer Research Results

LC3I, Lysosomal-associated membrane protein 2A: Click to Expand ⟱

Source:

Type:

LC3I (Lysosomal-associated membrane protein 2A, also known as LAMP2A) is a protein that plays a crucial role in the process of chaperone-mediated autophagy (CMA). CMA is a type of autophagy, a cellular process in which cells recycle and remove damaged or dysfunctional components.
LC3I is overexpressed in certain types of cancer, including breast, lung, and colon cancer.
The conversion of LC3-I to LC3-II (the lipidated form) is a key step in autophagy activation.

: In many cancers, low levels of LC3-I may indicate impaired autophagy, which can lead to the accumulation of damaged proteins and organelles, contributing to tumorigenesis. This is often associated with poor prognosis.
Tumor Promoting Role: In some contexts, the presence of LC3-I may indicate a baseline level of autophagy that is necessary for cellular homeostasis, but its role is less prominent compared to LC3-II.
Generally, decreased expression of LC3-I is associated with worse prognosis in many cancers, indicating its potential role in tumor suppression through the regulation of autophagy. However, the context-dependent nature of LC3-I's function suggests that further research is needed to fully understand its roles in different cancer types and its potential as a therapeutic target.

AML, Acute Myeloid Leukemia: Click to Expand ⟱

Acute Myeloid Leukemia

Scientific Papers found: Click to Expand⟱

5108-

SSE,

Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis

in-vitro,

AML,

U937

p‑P53↑, Beclin-1↓, LC3I↓, Apoptosis↑, Casp↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, Casp↑, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1, LC3I↓, 1,

DNA Damage & Repair ⓘ

p‑P53↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: LC3I, Lysosomal-associated membrane protein 2A

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells