IL10 Cancer Research Results

IL10, Interleukin-10: Click to Expand ⟱

Source:

Type:

IL-10 is a multifaceted immune-suppressive cytokine and possesses immune-regulatory and angiogenic functions.
It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions.
The role of IL-10 in tumor pathogenesis is currently highly controversial, with some findings showing that IL-10 promotes tumor development and angiogenesis, while others supporting that it inhibits tumor growth and metastasis.

IL-10 is often expressed in various cancers, including breast cancer, colorectal cancer, melanoma, and lymphoma. Its expression can vary significantly depending on the tumor type and the immune context.
Elevated levels of IL-10 are frequently associated with the presence of tumor-infiltrating immune cells, particularly Tregs and M2 macrophages.

AML, Acute Myeloid Leukemia: Click to Expand ⟱

Acute Myeloid Leukemia

Scientific Papers found: Click to Expand⟱

500-

MF,

Anti-Oxidative and Immune Regulatory Responses of THP-1 and PBMC to Pulsed EMF Are Field-Strength Dependent

in-vitro,

AML,

THP1

 wkEMF (<50 μT), mdEMF (<250 μT) and stEMF (<4.8 mT), 16.7Hz

compared to healty blood cells

ROS↑, Prx6↑, DHCR24↑, IL10↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Prx6↑, 1, ROS↑, 1,

Core Metabolism/Glycolysis ⓘ

DHCR24↑, 1,

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: IL10, Interleukin-10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells