AhR Cancer Research Results

AhR, aryl hydrocarbon receptor: Click to Expand ⟱
Source:
Type:
AhR is a ligand-activated transcription factor that plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and immune responses.
AhR is overexpressed in lung cancer cells and is associated with poor prognosis.
-Cell proliferation: AhR activation promotes cell growth and proliferation.
-Apoptosis: AhR activation inhibits apoptosis (programmed cell death), allowing cancer cells to survive.
-Angiogenesis: AhR activation promotes the formation of new blood vessels, which is essential for tumor growth.
-Immune suppression: AhR activation inhibits the immune response, allowing cancer cells to evade immune detection.
AhR regulates expression of CYP1A1, CYP1B1, and COX-2
AhR is often overexpressed in various types of cancer, including breast, lung, liver, and skin cancer. AhR expression is often higher in tumor cells compared to normal cells.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

AhR↑, 1,   Bcl-2↓, 1,   Fas↑, 1,   p27/CDKN1B↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   P21↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AhR, aryl hydrocarbon receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:584  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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