APAF1 Cancer Research Results

APAF1, Apoptotic Protease Activating Factor 1: Click to Expand ⟱
Source:
Type: protein
APAF1 (Apoptotic Protease Activating Factor 1) is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. APAF1 is a key component of the intrinsic pathway of apoptosis, which is activated in response to cellular stress or damage.
Downregulated in: breast, lung, prostate, colon (with poor prognosis)
APAF1 activators have been developed and are being tested in preclinical and clinical studies.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
3357- QC,    The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes
- in-vitro, AML, HL-60 - NA, NA, U937
DNMT1↓, DNMT3A↓, HDAC↓, ac‑H3↑, ac‑H4↑, BAX↑, APAF1↑, BNIP3↑, STAT3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

APAF1↑, 1,   BAX↑, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   STAT3↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: APAF1, Apoptotic Protease Activating Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:807  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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