APAF1 Cancer Research Results

APAF1, Apoptotic Protease Activating Factor 1: Click to Expand ⟱
Source:
Type: protein
APAF1 (Apoptotic Protease Activating Factor 1) is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. APAF1 is a key component of the intrinsic pathway of apoptosis, which is activated in response to cellular stress or damage.
Downregulated in: breast, lung, prostate, colon (with poor prognosis)
APAF1 activators have been developed and are being tested in preclinical and clinical studies.
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7588- I3C,    Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells
- in-vitro, AML, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, BAX↑, PUMA↑, NOXA↑, APAF1↑, NF-kB↓, IAP1↓, Bcl-xL↓, Bcl-2↓, XIAP↓, Myc↓, ChemoSen↑, Casp9↑, cl‑PARP↑, eff↑,
3357- QC,    The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes
- in-vitro, AML, HL-60 - NA, NA, U937
DNMT1↓, DNMT3A↓, HDAC↓, ac‑H3↑, ac‑H4↑, BAX↑, APAF1↑, BNIP3↑, STAT3↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 2,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp9↑, 1,   IAP1↓, 1,   Myc↓, 1,   NOXA↑, 1,   PUMA↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   STAT3↑, 1,   TumCG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Myc↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: APAF1, Apoptotic Protease Activating Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:807  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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