eff Cancer Research Results

eff, efficacy: Click to Expand ⟱
Source:
Type:
Power to enhance an anti cancer effect
AML, Acute Myeloid Leukemia: Click to Expand ⟱
Acute Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
4375- AgNPs,    The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells
- in-vitro, AML, K562
eff↑, ROS↑, Apoptosis↑, eff↓,
5341- Ajoene,    Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy
- Review, AML, NA
eff↑, AntiThr↑, Bacteria↓, LDH↓, TumCP↓, TumCCA↑, Bcl-2↓, Cyt‑c↑, Casp3↑,
5377- ART/DHA,    Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein
- in-vitro, AML, NA
AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, eff↑, other↓, eff↑, other↓,
5129- ART/DHA,    Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds
- in-vitro, AML, HL-60
Casp↑, Apoptosis↑, MMP↓, TumCCA↑, eff↑, eff↑,
2581- ART/DHA,  PB,    Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells
- in-vitro, AML, NA
eff↑, selectivity↑,
5867- CA,    Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines
- in-vitro, Pca, DU145 - in-vitro, Liver, Hep3B - in-vitro, AML, K562 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCP↓, eff↑, other↝,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1↓, ATG3↓, PI3K↓, Akt↓, eff↑,
4984- Dipy,  ATV,    Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
- in-vitro, AML, NA
eff↑, Apoptosis↑, selectivity↑, TumCG↓, HMG-CoA↓, HMGCR↑,
2501- EGCG,    A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea
- Case Report, AML, NA
OS↑, Remission↑, eff↑, Dose↝,
6110- EP,    Leukemic cell intracellular responses to nanosecond electric fields
- in-vitro, AML, NA
eff↑, EPR↑, other↝, other↝, Dose↝, Dose↝, Dose↝, eff↑,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
523- MF,  MTX,    Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage
- in-vitro, AML, THP1 - in-vitro, NA, PC12 - in-vivo, Cerv, HeLa
H2O2↑, TumCD↑, CellMemb↑, eff↑,
5184- PEITC,    Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
- vitro+vivo, AML, U937
Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,
1931- TQ,  doxoR,    Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms
- in-vivo, AML, NA
eff↑, tumCV↓, TumCCA↑, ROS↑, MMP↓, eff↑, TumVol↓, eff↑, Ki-67↓,
3114- VitC,    Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
- in-vitro, AML, NA
TET2↑, eff↑, ROS↑, Fenton↑, Hif1a↓,
1836- VitC,  VitK3,  Chemo,    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib
- in-vitro, AML, NA
tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,

Showing Research Papers: 1 to 18 of 18

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   Ferroptosis↑, 1,   GSH↝, 1,   H2O2↑, 1,   Iron↑, 1,   Mets↑, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

HMG-CoA↓, 1,   LDH↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 7,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Bcl-xL↑, 1,   cl‑BID↑, 1,   Casp↑, 3,   Casp3↑, 3,   Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   JNK↑, 1,   Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   Proteasome↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 3,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↓, 1,   Beclin-1↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

HMGCR↑, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

Ki-67↓, 1,   TumCP↓, 3,  

Angiogenesis & Vasculature ⓘ

EPR↑, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 25,   selectivity↑, 3,   TET2↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   OS↑, 1,   Remission↑, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 67

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: eff, efficacy
3 Artemisinin
2 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Ajoene (compound of Garlic)
1 Phenylbutyrate
1 Carnosic acid
1 Capsaicin
1 Cat’s Claw
1 Dichloroacetophenone(2,2-)
1 Dipyridamole
1 Atorvastatin
1 EGCG (Epigallocatechin Gallate)
1 Electrical Pulses
1 Gambogic Acid
1 verapamil
1 Magnetic Fields
1 methotrexate
1 Phenethyl isothiocyanate
1 Thymoquinone
1 doxorubicin
1 VitK3,menadione
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:2  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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