MPO Cancer Research Results

MPO, myeloperoxidase (MPO): Click to Expand ⟱

Source:

Type:

Myeloperoxidase (MPO) is a heme-containing peroxidase most commonly associated with neutrophils and certain other myeloid cells. It plays a critical role in the innate immune response by generating reactive oxygen species (ROS) during the respiratory burst, which can destroy pathogens.

MPO is predominantly expressed in neutrophils and monocytes, where it catalyzes the formation of hypochlorous acid (HOCl) and other ROS from hydrogen peroxide and chloride ions.
The generation of ROS by MPO is essential for antimicrobial defense; however, these reactive molecules can also induce oxidative stress in the tumor microenvironment.

MPO is not typically expressed by tumor cells themselves, but high levels can be found in tumor-infiltrating immune cells (e.g., neutrophils) or in areas of chronic inflammation.

Ovarian, Ovarian Cancer: Click to Expand ⟱

Ovarian Cancer

Scientific Papers found: Click to Expand⟱

1874-

DCA,

Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress

in-vitro,

Ovarian,

SKOV3

 20, 40, and 80 mg/mL DCA doses,

in-vitro,

Ovarian,

MDAH-2774

Apoptosis↑, MPO↓, iNOS↓, Hif1a↓, SOD↑, Casp3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

MPO↓, 1, SOD↑, 1,

Cell Death ⓘ

Apoptosis↑, 1, Casp3↑, 1, iNOS↓, 1,

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: MPO, myeloperoxidase (MPO)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells