Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱

Source:

Type: pro-survival proteins

The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.

Ovarian, Ovarian Cancer: Click to Expand ⟱

Ovarian Cancer

Scientific Papers found: Click to Expand⟱

266-

ALA,

Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death

in-vitro,

Ovarian,

IGROV1

Mcl-1↓, Bcl-xL↓, BIM↑, ROS↑,

577-

Api,

PacT,

Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells

in-vitro,

Ovarian,

SKOV3

40uM

p‑Akt↓, Bcl-xL↓, Bcl-2↓, AXL↓, Tyro3↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ROS↑, 1,

Cell Death ⓘ

p‑Akt↓, 1, Bcl-2↓, 1, Bcl-xL↓, 2, BIM↑, 1, Mcl-1↓, 1,

Migration ⓘ

AXL↓, 1, Tyro3↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells