Lysosomes are membrane-bound organelles that play a crucial role in cellular homeostasis by degrading and recycling various biomolecules, including proteins, lipids, and carbohydrates. They contain a variety of hydrolytic enzymes that facilitate these processes. In the context of cancer, lysosomes are increasingly recognized for their roles in tumor biology, influencing cell survival, proliferation, and metastasis.
Lysosomes are generally considered protumorigenic in many contexts. Their role in degrading extracellular matrix components and releasing proteolytic enzymes can facilitate tumor cell invasion and metastasis. Additionally, lysosomes can support cancer cell survival by providing nutrients through autophagy and recycling processes.
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