TET3 Cancer Research Results
TET3, Ten-Eleven Translocation methylcytosine dioxygenase 3: Click to Expand ⟱
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Tet3 (Ten-Eleven Translocation methylcytosine dioxygenase 3) is one of the three members of the TET family of enzymes that play a central role in the active demethylation of DNA.
-Tet3 is particularly important during embryonic development.
-Altered Tet3 expression—either upregulation or downregulation—has been reported
-Some studies suggest that Tet3 may act as a tumor suppressor by maintaining proper epigenetic programming; conversely, in other contexts, its activity might support oncogenic pathways, particularly if the demethylation process activates genes that favor tumor growth or metastasis.
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Ovarian, Ovarian Cancer: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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in-vitro, |
Ovarian, |
SKOV3 |
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Warburg↓, miR-145↑, HK2↓, TET3↑, Glycolysis↓, PKM2↓, GLUT1↓, LDH↓, PFK2↓, PDK1↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
Glycolysis↓, 1, HK2↓, 1, LDH↓, 1, PDK1↓, 1, PFK2↓, 1, PKM2↓, 1, Warburg↓, 1,
Transcription & Epigenetics ⓘ
miR-145↑, 1, TET3↑, 1,
Barriers & Transport ⓘ
GLUT1↓, 1,
Clinical Biomarkers ⓘ
LDH↓, 1,
Total Targets: 11
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: TET3, Ten-Eleven Translocation methylcytosine dioxygenase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:20 Cells:% prod#:% Target#:1327 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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