TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱

Source:

Type:

Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.

Ovarian, Ovarian Cancer: Click to Expand ⟱

Ovarian Cancer

Scientific Papers found: Click to Expand⟱

4563-

AgNPs,

Rad,

Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study

in-vitro,

BC,

MCF7

in-vitro,

Ovarian,

SKOV3

in-vitro,

GBM,

U87MG

in-vitro,

Melanoma,

A431

RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,

358-

AgNPs,

Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer

vitro+vivo,

Ovarian,

SKOV3

 mice

TumCCA↑, ROS↑, Casp3↑, TumCG↓, cycD1/CCND1↓,

1363-

Ash,

doxoR,

Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

in-vitro,

Ovarian,

A2780S

in-vitro,

Ovarian,

CaOV3

in-vivo,

NA,

in vivo xenograft model of ovarian cancer.

ChemoSen↑, ROS↑, DNAdam↑, TumCCA↑, LC3B↑, TumCG↓, cl‑Casp3↑,

1520-

Ba,

Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells

in-vitro,

Ovarian,

SKOV3

50–200 µM baicalein for 48 and 72 h

54uM

in-vitro,

Ovarian,

TOV-21G

91uM

TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,

6500-

BCP,

Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis

in-vitro,

Ovarian,

TumCP↓, TumCCA↑, Apoptosis↑, Casp3↑, cl‑PARP↑,

2791-

CHr,

Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

in-vitro,

Ovarian,

OV90

TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,

4776-

CoQ10,

Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy

vitro+vivo,

Ovarian,

SKOV3

(SKOV-3) cells and xenografted nude mice

ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1/ATG6↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,

6292-

Cro,

Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms

in-vitro,

Cerv,

HeLa

 crocetin (60-240 μmol/L) for 48 h

in-vitro,

Lung,

A549

in-vitro,

Ovarian,

SKOV3

TumCP↓, TumCCA↑, P21↑, Apoptosis↑, eff↑,

7118-

GEO2,

Germanium oxide inhibits the transition from G2 to M phase of CHO cells

in-vitro,

Ovarian,

Chinese hamster ovary (CHO) cells

TumCCA↑, CDK1↓,

8063-

KAE,

Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways

in-vitro,

Ovarian,

Dose↓, selectivity↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, TumCCA↑, MEK↓, ERK↓, STAT3↓,

8209-

LCA,

Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells

in-vitro,

Ovarian,

SKOV3

19.22 μM at 24 h

tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,

8187-

LGE,

Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation

in-vitro,

BC,

4T1

in-vitro,

Ovarian,

OVCAR-3

in-vitro,

Ovarian,

SKOV3

TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,

5803-

MET,

carbop,

Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells

in-vitro,

Ovarian,

A2780S

Metformin at 20 µmol/L was selected for further study

in-vitro,

Ovarian,

SKOV3

eff↑, ChemoSen↑, TumCCA↑,

51-

QC,

Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines

in-vitro,

Ovarian,

SKOV3

 50 uM

cycD1/CCND1↓, TumCCA↑,

52-

QC,

Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines

in-vitro,

BC,

MCF7

in-vitro,

Ovarian,

SKOV3

in-vitro,

OS,

U2OS

Bcl-2↓, BAX↑, PI3K/Akt↓, cycD1/CCND1↓, TumCCA↑,

5327-

TFdiG,

Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells

in-vitro,

Ovarian,

A2780S

23.81 μM

TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,

5020-

UA,

Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway

in-vitro,

Ovarian,

 IC50 of 35 µM in cancer cells and IC50 of 75 µM in normal cell lines

tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

EDEM↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 9,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1, chemoP↑, 1,
Total Targets: 72

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest

2 Silver-NanoParticles
2 Quercetin
1 Radiotherapy/Radiation
1 Ashwagandha(Withaferin A)
1 doxorubicin
1 Baicalein
1 Beta-Caryophyllene
1 Chrysin
1 Coenzyme Q10
1 Crocetin
1 Germanium inorganic
1 Kaempferol
1 Licochalcone A
1 Lemongrass Extract/Citral
1 Metformin
1 carboplatin
1 Aflavin-3,3′-digallate
1 Ursolic acid

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:322  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

TumCCA Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

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