TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
358- AgNPs,    Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer
- vitro+vivo, Ovarian, SKOV3
TumCCA↑, ROS↑, Casp3↑, TumCG↓, cycD1/CCND1↓,
1363- Ash,  doxoR,    Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, CaOV3 - in-vivo, NA, NA
ChemoSen↑, ROS↑, DNAdam↑, TumCCA↑, LC3B↑, TumCG↓, cl‑Casp3↑,
1520- Ba,    Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, TOV-21G
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,
5803- MET,  carbop,    Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, SKOV3
eff↑, ChemoSen↑, TumCCA↑,
51- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, Ovarian, SKOV3
cycD1/CCND1↓, TumCCA↑,
52- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, BC, MCF-7 - in-vitro, Ovarian, SKOV3 - in-vitro, OS, U2OS
Bcl-2↓, BAX↑, PI3K/Akt↓, cycD1/CCND1↓, TumCCA↑,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,
5020- UA,    Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway
- in-vitro, Ovarian, NA
tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 7,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   PI3K/Akt↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 4,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp3↑, 1,   cl‑Casp3↑, 2,   Chk2↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   MAPK↑, 1,   MDM2↓, 1,   p38↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   p‑p70S6↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   ERStress↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↑, 1,   LC3s↑, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 3,   P53↑, 1,   PCNA↓, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 4,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   TumCG↓, 5,  

Migration ⓘ

Ca+2↑, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose∅, 1,   eff↓, 2,   eff↑, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

HER2/EBBR2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,  
Total Targets: 53

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
2 Silver-NanoParticles
2 Quercetin
1 Radiotherapy/Radiation
1 Ashwagandha(Withaferin A)
1 doxorubicin
1 Baicalein
1 Chrysin
1 Coenzyme Q10
1 Metformin
1 carboplatin
1 Aflavin-3,3′-digallate
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:322  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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