LC3s Cancer Research Results

LC3s, Autophagosome Proteins: Click to Expand ⟱
Source:
Type:
LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in autophagy remains obscure.
Protumorigenic: In many cases, especially in advanced cancers, increased autophagy (reflected by high LC3 levels) can support tumor growth by providing nutrients and promoting cell survival under stress conditions.
Antitumorigenic: Conversely, in early-stage tumors or in response to certain therapies, autophagy can act as a tumor suppressor by preventing the accumulation of damaged organelles and proteins.
Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
4776- CoQ10,    Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells via induction of ROS-mediated apoptosis and cytoprotective autophagy
- vitro+vivo, Ovarian, SKOV3
ROS↑, eff↓, AntiCan↑, Apoptosis↑, tumCV↓, TumCG↓, TumCCA↑, LC3s↑, ERStress↑, Beclin-1↑, Bax:Bcl2↑, HER2/EBBR2↓, Akt↓, mTOR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ERStress↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3s↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Clinical Biomarkers ⓘ

HER2/EBBR2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LC3s, Autophagosome Proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:492  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page