GADD45A Cancer Research Results

GADD45A, Growth Arrest and DNA Damage-inducible 45 alpha: Click to Expand ⟱
Source:
Type: TSG/protein
GADD45A (Growth Arrest and DNA Damage-inducible 45 alpha) is a protein that plays a crucial role in various cellular processes, including cell cycle regulation, DNA repair, and apoptosis.
GADD45A is a tumor suppressor gene that is often downregulated in various types of cancer, including breast, lung, and colon cancer.
Ovarian, Ovarian Cancer: Click to Expand ⟱
Ovarian Cancer
Scientific Papers found: Click to Expand⟱
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

EDEM↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

GADD45A↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GADD45A, Growth Arrest and DNA Damage-inducible 45 alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:20  Cells:%  prod#:%  Target#:718  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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