Database Query Results : , ,

PC, Pancreatic Cancer: Click to Expand ⟱

Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑

Scientific Papers found: Click to Expand⟱

Aco,

Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

in-vitro,

PC,

PANC1

 0.75–6uM

in-vitro,

Pca,

DU145

HH↓, PTCH1↓, Bcl-2↓, Gli1↓,

274-

ALA,

LDN,

Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases

Human,

PC,

OS↑,

1354-

And,

Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer

in-vitro,

PC,

0, 10, 20, 40 µM

in-vivo,

PC,

Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,

589-

Api,

5-FU,

Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro

in-vitro,

PC,

Bxpc-3

0-50 uM

 (0, 6, 24 and 42 h) of flavonoids

GSK‐3β↓, NF-kB↓,

315-

Api,

Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer

vitro+vivo,

PC,

Panc02

 20 uM

CK2↓, CD4+↑, CD8+↑, Ikaros↑,

1537-

Api,

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Review,

PC,

20-80uM

5-50mg/kg

TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

1362-

Ash,

GEM,

Synergistic Inhibition of Pancreatic Cancer Cell Growth and Migration by Gemcitabine and Withaferin A

in-vitro,

PC,

PANC1

28nM(GC), 18uM(WFA)

in-vitro,

PC,

Hs766t

63nM(GC), 13uM(WFA)

ChemoSen↑, ROS↑, Apoptosis↑, TumCMig↓, F-actin↓, YMcells↓, NF-kB↓,

2003-

Ash,

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

in-vitro,

Pca,

PC3

2 μM WA

in-vitro,

Pca,

DU145

in-vitro,

Nor,

TIG-1

in-vitro,

PC,

LNCaP

TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,

2597-

Ba,

Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer

Review,

PC,

chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,

1384-

BBR,

Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines

in-vitro,

PC,

PANC1

TumCCA↑, ROS↑, Apoptosis↑,

940-

BBR,

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression

vitro+vivo,

PC,

PANC1

33uM-62uM

253 patients who were treatment‐naive and pathologically diagnosed with pancreatic adenocarcinoma

in-vivo,

PC,

MIA PaCa-2

mouse

LDHA↓, lactateProd↓, AMPKα↓, TumVol↓, Ki-67↓,

2750-

BetA,

GEM,

Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation

in-vitro,

PC,

Bxpc-3

in-vitro,

Lung,

H1299

CHK1↓, ChemoSen↑, tumCV↓, Apoptosis↑, DNAdam↑,

3525-

Bor,

Synthesis of DNA-Boron Cluster Composites and Assembly into Functional Nanoparticles with Dual, Anti-EGFR, and Anti-c-MYC Oncogene Silencing Activity

in-vitro,

PC,

PANC1

EGFR↓, cMyc↓,

755-

Bor,

https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and

in-vitro,

Pca,

DU145

in-vitro,

PC,

PC3

TumCG↓, Apoptosis↑,

1423-

Bos,

Acetyl-11-keto-β-Boswellic Acid Suppresses Invasion of Pancreatic Cancer Cells Through The Downregulation of CXCR4 Chemokine Receptor Expression

in-vitro,

Melanoma,

U266

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

SkBr3

in-vitro,

PC,

PANC1

CXCR4↓, TumCI↓, HER2/EBBR2↓, NF-kB↓,

2014-

CAP,

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

Bxpc-3

150uM

in-vitro,

Nor,

HPDE-6

150uM

normal pancreatic epithelial cells were resistant to the effects of capsaicin.

in-vivo,

PC,

AsPC-1

mice orally fed with 2.5 mg/kg capsaicin

mice, 2.5 mg/kg capsaicin was given to mice by oral gavage, which is 0.202 mg/kg when converted to human equivalent dose (HED) and equates to 13.2 mg dose of capsaicin for a 60 kg person

ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,

1577-

Citrate,

Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet

in-vivo,

PC,

30 mg·kg ·day citrate(injection)

mice

in-vitro,

PC,

PANC1

10 mmol·L citrate

in-vitro,

PC,

PATU-8988

in-vitro,

PC,

MIA PaCa-2

Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,

1580-

Citrate,

Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway

in-vitro,

Pca,

PC3

 (0-3 mM)

in-vivo,

PC,

50 mg/kg/day, i.p.)

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

WPMY-1

 (0-3 mM)

Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1↑, TumAuto↑, CaMKII ↓,

1584-

Citrate,

Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, eff↑, Ki-67↓, eff↑,

4761-

CoQ10,

Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer

in-vitro,

PC,

in-vivo,

PC,

MIA PaCa-2 xenograft mouse model

*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,

2980-

CUR,

Inhibition of NF B and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation

in-vivo,

PC,

mice

TumCG↓, p50↓, p65↓, NF-kB↓, Sp1/3/4↓, MMP↓, ROS↑,

11-

CUR,

Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

in-vitro,

PC,

PANC1

HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓,

474-

CUR,

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

in-vitro,

PC,

PANC1

6, 10 and 12 µM, 24 h

in-vitro,

PC,

MIA PaCa-2

TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,

475-

CUR,

Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway

in-vitro,

PC,

PANC1

2.5, 5, 10 and 20 µM, 72 h

Apoptosis↑, cl‑Casp3↑, miR-340↑, cl‑PARP↑, XIAP↓,

476-

CUR,

The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer

in-vitro,

PC,

PATU-8988

5, 10, 15 and 20 μM, 48 and 72 h

in-vitro,

PC,

PANC1

TumCMig↓, TumCI↓, Apoptosis↑, NEDD9↓, p‑Akt↓, p‑mTOR↓, PTEN↑, p73↑, β-TRCP↑,

19-

Deg,

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway

in-vitro,

PC,

Bxpc-3

in-vitro,

PC,

PANC1

 0-20uM-1wk

HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓,

1847-

dietFMD,

VitC,

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

in-vitro,

PC,

PANC1

vitamin C (≥0.3 mM)

TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,

2165-

dietP,

SFN,

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Trial,

PC,

Dose↝, OS↑, eff↝,

27-

EA,

Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice

in-vivo,

PC,

HH↓, Gli1↓, GLI2↓, cycD1/CCND1↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Akt↓, Shh↓, Snail↓, MMP2↓, MMP9↓, BAX↑, E-cadherin↑, NOTCH3↓, HEY1↓,

22-

EGCG,

Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

in-vitro,

PC,

CD133+

in-vitro,

PC,

CD44+

in-vitro,

PC,

CD24+

in-vitro,

PC,

ESA+

 20-60 uM

HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, EMT↓, survivin↓, Nanog↓, Casp3↑, Casp7↑,

688-

EGCG,

GEM,

Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine

in-vitro,

PC,

Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,

2309-

EGCG,

Chemo,

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts

in-vitro,

PC,

MIA PaCa-2

(20–100 μM) for 72 h

in-vitro,

Nor,

HPNE

in-vitro,

PC,

PANC1

in-vivo,

NA,

mice

TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,

2860-

FIS,

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

in-vitro,

PC,

PANC1

in-vitro,

PC,

Bxpc-3

in-vitro,

Nor,

hTERT-HPNE

in-vivo,

NA,

mice

AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,

1962-

GamB,

HCQ,

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

in-vitro,

PC,

LC3II↑, Beclin-1↑, p62↓, MMP↓, ROS↑, TumAuto↑, eff↑,

808-

GAR,

CUR,

Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells

in-vitro,

PC,

Bxpc-3

10uM(Gar), 5uM(Cur)

combination of garcinol and curcumin was 2 to 10 fold that of the individual agents

in-vitro,

PC,

PANC1

tumCV↓, Apoptosis↑, Casp3↑, Casp9↑,

816-

GAR,

Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells

in-vitro,

PC,

PANC1

significantly suppressed the stem-like properties

Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,

813-

GAR,

GEM,

Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model

in-vivo,

PC,

mouse

TumCG↓, OS↑,

810-

GAR,

GEM,

Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures

in-vitro,

PC,

 Garcinol synergizes with gemcitabine to inhibit cell proliferation and induce apoptosis

TumCP↓, Apoptosis↑, PARP↝, VEGF↝, MMPs↝, Casp↝, NF-kB↝, miR-21↝,

807-

GAR,

Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells

in-vitro,

PC,

PANC1

0-40 μM

in-vitro,

PC,

Bxpc-3

TumCG↓, Apoptosis↑, TumCCA↑,

1186-

Gb,

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

in-vitro,

PC,

in-vitro,

Nor,

HUVECs

in-vivo,

PC,

tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,

30-

Ger,

A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells

in-vitro,

PC,

PANC1

 (IC 50) values of 6,.9 uM

in-vitro,

PC,

AsPC-1

 5.1 uM

HH↓, Gli1↓, Shh↓, cycD1/CCND1↓,

4509-

GLA,

Gamma-linolenic Acid (GLA) sensitizes pancreatic cancer cells to gemcitabine

in-vitro,

PC,

PANC1

tumCV↑, selectivity↑, ChemoSen↑,

836-

Gra,

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism

vitro+vivo,

PC,

mice

Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,

850-

Gra,

Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin

in-vitro,

PC,

PC3

0.1uM(Annonacin) 55ug/mL(EAB)

without impacting RWPE-1 normal prostate cells

in-vitro,

Pca,

DU145

ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,

108-

GSL,

A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells

in-vitro,

PC,

PANC1

  6.9 uM

in-vitro,

PC,

AsPC-1

  5.1 uM

in-vitro,

PC,

C3H10T1/2

  35.7 uM

HH↓, Gli1↓, cycD1/CCND1↓,

HCO3,

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana

in-vitro,

PC,

HaCaT

in-vitro,

Pca,

PANC1

HH↓, Gli1↓, PTCH1↓, Bcl-2↓,

2881-

HNK,

Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis

in-vitro,

PC,

PANC1

 50 µM

tumCV↓, Casp3↑, Apoptosis↑, TumCCA↑, TumCI↓, Mcl-1↓, EMT↓,

2882-

HNK,

Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling

in-vitro,

PC,

PANC1

TumCI↓, TumCMig↓, p‑SMAD2↓, p‑SMAD3↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, Snail↓, Slug↓, Rho↓, ROCK1↓,

1277-

I3C,

GEN,

Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein

in-vitro,

PC,

PANC1

>10uM

STAT3↓, Apoptosis↑,

974-

JG,

Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro

in-vitro,

PC,

MIA PaCa-2

100nM-10uM

Hif1a↓, VEGF↓, p‑Akt↓, TumCP↓, TumCI↓,

1920-

JG,

TQ,

Plum,

Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line

in-vitro,

PC,

PANC1

ROS↑, TumCMig↓, MMP9↓,

1921-

JG,

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

in-vitro,

PC,

vitro+vivo,

PC,

TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,

1534-

LT,

Api,

EGCG,

RES,

Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

in-vitro,

PC,

Bxpc-3

TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,

4779-

Lyco,

Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

PANC1

ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,

4520-

MAG,

Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling

vitro+vivo,

PC,

PANC1

mice

Vim↓, E-cadherin↑, EMT↓, N-cadherin↓, p‑SMAD2↓, p‑SMAD3↓, TumCP↓, TumCMig↓, TumCI↓, TGF-β↓,

2251-

MF,

Rad,

BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage

in-vitro,

Lung,

A549

 0 μT to 35 μT and a mattress applicator

in-vitro,

HNSCC,

UTSCC15

in-vitro,

CRC,

DLD1

in-vitro,

PC,

MIA PaCa-2

RadioS↑, DNAdam↑, ROS↑, ChemoSen∅, Pyruv↓, ADP:ATP↓, ROS↑,

524-

MF,

Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)

vitro+vivo,

PC,

MS-1

2mT, 50Hz

mouse cell line injected in mice

vitro+vivo,

PC,

HUVECs

other↓, TumCP↓, TumCMig↓, VEGFR2↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,

215-

MFrot,

MF,

Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields

in-vitro,

PC,

CAF

 1 Hz and 40 mT

 superparamagnetic iron oxide nanoparticles

TumVol↓, lysoMP↑, CAFs/TAFs↓, eff↑,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

in-vitro,

CRC,

SW-620

23% reduction

in-vitro,

NA,

HT1080

37% reduction

in-vitro,

Pca,

PC3

40% reduction

in-vitro,

OS,

U2OS

46% reduction

in-vitro,

BC,

MCF-7

33% reduction

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, eff↑, *TumCG∅,

4977-

Nimb,

Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis

vitro+vivo,

PC,

AsPC-1

in-vitro,

PC,

PANC1

SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,

4976-

Nimb,

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

vitro+vivo,

PC,

ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,

1225-

OLST,

Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway

vitro+vivo,

PC,

TumCMig↓, TumCI↓, Ferroptosis↑, MAPK↓,

2061-

PB,

Chemo,

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells

in-vitro,

PC,

PANC1

in-vitro,

PC,

COLO357

in-vitro,

PC,

Bxpc-3

HDAC↓, Apoptosis↑, eff↑, selectivity↑, TumCCA↑, eff↑, selectivity↑,

2067-

PB,

Histone Deacetylase (HDAC) Inhibitors: Current Evidence for Therapeutic Activities in Pancreatic Cancer

in-vitro,

PC,

HDAC↓, HATs↑,

1674-

PBG,

SDT,

HPT,

Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells

in-vitro,

PC,

PANC1

in-vitro,

Nor,

H6c7

tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,

5014-

PEITC,

Xan,

Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

in-vitro,

PC,

NF-kB↓, NRF2↑, GSTP1/GSTπ↑, NQO1↑, SOD↑, TumCP↓,

34-

PFB,

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

in-vitro,

PC,

PANC1

HH↓, Gli1↓, GLI2↓, PTCH1↓, Bcl-2↓,

2956-

PL,

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

in-vitro,

PC,

ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,

2940-

PL,

Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors

in-vitro,

PC,

PANC1

 5-15 μM

in-vitro,

Lung,

A549

in-vitro,

Kidney,

786-O

in-vitro,

BC,

SkBr3

ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,

4702-

PTS,

Pterostilbene Inhibits Pancreatic Cancer In Vitro

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

tumCV↓, TumCG↓, BioAv↑,

57-

QC,

Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo

vitro+vivo,

PC,

 25,50 and 100 uM

TSP-1↑,

56-

QC,

Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells

in-vitro,

PC,

PANC1

 245uM

in-vitro,

PC,

PATU-8988

 131 uM

EMT↓, MMPs↓, MMP2↓, MMP7↓, STAT3↓,

102-

RES,

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

in-vitro,

PC,

MIA PaCa-2

HH↓, PTCH1↓, Smo↓, HH↓, EMT↓, PI3K/Akt↓, NF-kB↓,

967-

RES,

Resveratrol binds and inhibits transcription factor HIF-1α in pancreatic cancer

Analysis,

PC,

silico approach

Hif1a↓,

881-

RES,

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

PANC1

in-vitro,

Pca,

DU145

TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,

3052-

RES,

Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways

in-vitro,

PC,

PANC1

0, 25, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h,

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

Bxpc-3

NAF1↓, ROS↑, NRF2↑, eff↑, TumCG↓,

3082-

RES,

Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

in-vivo,

NA,

mice

VEGF↓, CXCL12↓, IL6↓, α-SMA↓, Hif1a↓, TumCI↓, EMT↓,

3035-

RosA,

Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling

in-vitro,

PC,

in-vivo,

NA,

Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27↑,

1251-

RT,

OLST,

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions

in-vitro,

BC,

MCF-7

in-vitro,

PC,

PANC1

in-vivo,

NA,

EAC, mice

TumVol↓, *CEA↓, *FASN↓, *ROS↓, *MDA↓, *GSH↑, Apoptosis↑,

110-

SFN,

Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway

in-vivo,

PC,

 20 mg/kg

HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓,

3196-

SFN,

Sulforaphane eradicates pancreatic cancer stem cells by NF-κB

Review,

PC,

CSCs↓, NF-kB↓,

1733-

SFN,

Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal

in-vitro,

PC,

PanCSC

in-vitro,

Nor,

HPNE

in-vitro,

Nor,

HNPSC

CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,

1456-

SFN,

Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells

in-vitro,

PC,

MIA PaCa-2

 0, 7.5, and 15 µM

in-vitro,

PC,

PANC1

tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,

2167-

SFN,

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

Casp8↑, MMP↓, Casp3↑, Apoptosis↑, GSH↓, GSH↑,

1140-

SIL,

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

in-vitro,

PC,

AsPC-1

10 μM to 250 μM

~75uM

in-vivo,

PC,

mouse

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

PANC1

in-vitro,

PC,

Bxpc-3

TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,

1073-

SK,

Chemo,

Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells

in-vitro,

PC,

PANC1

7.252 ± 0.054 μM

in-vitro,

PC,

Bxpc-3

PAK1↓, TumCP↓, Apoptosis↑, ChemoSen↑, ROS↑,

3045-

SK,

Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)

in-vitro,

PC,

MIA PaCa-2

ECAR↓, Glycolysis↓, ATP↓, PKM2↓, TumCMig↓, Ca+2↑, GlucoseCon↓, lactateProd↓, MMP↓, ROS↑,

343-

SNP,

Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma

in-vitro,

PC,

PANC1

 3.19 or 1.67 ug/mL

BAX↑, Bcl-2↓, P53↑, TumAuto↑,

375-

SNP,

ALA,

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer

in-vitro,

PC,

Bxpc-3

 we used α-lipoic acid concentrations of 0.5 and 1 mM

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

in-vivo,

NA,

dropping 200 µL or 400 µL of a 14 ppm AgNP solution, 200 µL or 400 µL of a 0.5 mM α-lipoic acid solution, or both solutions together on the chorioallantoic membrane (CAM)

chick embryos

mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,

4541-

SNP,

RosA,

Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities

in-vitro,

Nor,

WI38

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

PANC1

*antiOx↑, TumCD↓, selectivity↑,

4558-

SNP,

Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

in-vitro,

PC,

PANC1

3.19 ug/mL

ROS↑, selectivity↑, NO↑, SOD↓, GPx4↓, Catalase↓, TumCCA↑, MMP↓,

4411-

SNP,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

in-vitro,

Lung,

A549

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

962-

TQ,

Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways

in-vitro,

PC,

PANC1

0, 5, 10, 15, 20, 25, 30, and 35 µM

11uM

 experiments were constructed in hypoxic conditions (O2 content was 1%)

in-vitro,

Nor,

hTERT-HPNE

no effect

normal pancreatic duct epithelial (hTERT-HPNE) cells

in-vitro,

PC,

AsPC-1

11uM

in-vitro,

PC,

Bxpc-3

26uM

TumCMig↓, TumCI↓, Apoptosis↑, Hif1a↓, PI3k/Akt/mTOR↓, TumCCA↑, *toxicity↓, *TumCI∅, *TumCMig∅,

3402-

TQ,

Enhanced Apoptosis in Pancreatic Cancer Cells through Thymoquinone-rich Nigella sativa L. Methanol Extract: Targeting NRF2/HO-1 and TNF-α Pathways

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

tumCV↓, NRF2↑, HO-1↑, TNF-α↓,

2103-

TQ,

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells

in-vitro,

PC,

Hs766t

25–75 µM

in-vitro,

PC,

MIA PaCa-2

MCP1↓, TNF-α↓, IL1β↓, COX2↓, NF-kB↓, HDAC↓, P21↑,

2105-

TQ,

Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation

in-vitro,

PC,

AsPC-1

10–50 μM

in-vitro,

PC,

MIA PaCa-2

in-vitro,

PC,

Hs766t

in-vivo,

NA,

mice

tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,

2353-

TQ,

The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

Review,

PC,

BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,

4853-

Uro,

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer

vitro+vivo,

PC,

MIA PaCa-2

Mice in the Uro A (20 mg/kg/day) arm received treatment by oral gavage 5 days/week

15.8– 24.8 μmol/L

in-vitro,

NA,

PANC1

p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,

1888-

VitB1/Thiamine,

DCA,

High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate

in-vitro,

PC,

SK-N-BE

NA,

PC,

PANC1

p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,

622-

VitC,

Treatment of Pancreatic Cancer with Pharmacological Ascorbate

vitro+vivo,

PC,

H2O2↑,

3140-

VitC,

Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Nor,

HEK293

citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,

3130-

VitC,

Effect of high-dose vitamin C on MMP2 expression and invasive ability in human pancreatic cancer cell line PANC-1

in-vitro,

PC,

PANC1

MMP2↓, TumCI↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 103

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 1, CD8+↑, 1,
Total Targets: 300

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 2, GSH↑, 1, MDA↓, 1, ROS↓, 1, ROS∅, 2,

Mitochondria & Bioenergetics ⓘ

ETC↝, 1,

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG∅, 1,

Migration ⓘ

CEA↓, 1, TumCI∅, 1, TumCMig∅, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 2,

Clinical Biomarkers ⓘ

CEA↓, 1,

Functional Outcomes ⓘ

toxicity↓, 4, toxicity↑, 1, toxicity∅, 2,
Total Targets: 17

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , ,

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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