glut Cancer Research Results

glut, glutamine: Click to Expand ⟱

Source:

Type:

Glutamine is an amino acid that fuels various metabolic pathways, supporting bioenergetics, biosynthesis, and redox balance in cancer cells.

-Many breast tumors exhibit glutamine addiction, relying on enhanced glutamine uptake and metabolism to support rapid proliferation.

-In many tumor types—such as breast, lung, colorectal, liver, and pancreatic cancers—enhanced glutamine metabolism is often associated with a more aggressive phenotype, therapy resistance, and poorer patient outcomes.

Pca, Prostate Cancer: Click to Expand ⟱

Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.

Scientific Papers found: Click to Expand⟱

119-

UA,

CUR,

RES,

Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

ROS⇅, p‑STAT3↓, Src↓, AMPK↑, GlutMet↑, TCA↑, glut↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ROS⇅, 1,

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1, glut↓, 1, GlutMet↑, 1, TCA↑, 1,

Proliferation, Differentiation & Cell State ⓘ

Src↓, 1, p‑STAT3↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: glut, glutamine

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells