GLO-I Cancer Research Results

GLO-I, glyoxalase I: Click to Expand ⟱

Source:

Type:

GLO-I, or glyoxalase I, is an enzyme that plays a crucial role in the detoxification of reactive carbonyl species, particularly methylglyoxal, which is a byproduct of various metabolic processes.
-Glyoxalase-I (Glo-I) and glyoxalase-II (Glo-II) comprise the glyoxalase system and are responsible for the detoxification of methylglyoxal (MGO). MGO is formed non-enzymatically as a by-product, mainly in glycolysis, and leads to the formation of advanced glycation endproducts (AGEs).
-Elevated levels of GLO-I in cancer cells can help them cope with these toxic byproducts, promoting cell survival and proliferation.
-High levels of GLO-I may be associated with tumor progression and poor prognosis in certain types of cancer.
-Inhibiting GLO-I could sensitize cancer cells to chemotherapy and other treatments by increasing their vulnerability to oxidative stress.
-Many studies have reported that GLO-I is overexpressed in several types of cancers, including breast, lung, prostate, colorectal, and pancreatic cancers. This overexpression is often associated with aggressive tumor behavior and poor prognosis.
Inhibitors: – Several flavonoids such as quercetin, luteolin, and fisetin have been shown to inhibit glyoxalase I activity in enzyme assays. - Curcumin. - Resveratrol - EGCG

Pca, Prostate Cancer: Click to Expand ⟱

Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.

Scientific Papers found: Click to Expand⟱

409-

CUR,

Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor Activity

in-vitro,

Pca,

PC3

7.9 µM

in-vitro,

BC,

MDA-MB-231

GLO-I↓, GSH↓, ATP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSH↓, 1,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,

Core Metabolism/Glycolysis ⓘ

GLO-I↓, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GLO-I, glyoxalase I

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells