ETC Cancer Research Results

ETC, Electron Transport Chain: Click to Expand ⟱
Source:
Type:
The electron transport chain (ETC) — the mitochondrial system that produces ATP through oxidative phosphorylation — is deeply linked to cancer biology, both in tumor promotion and suppression.
-The ETC resides in the inner mitochondrial membrane and includes Complexes I–IV and ATP synthase (Complex V).
-It transfers electrons from NADH/FADH₂ to oxygen, generating ATP and reactive oxygen species (ROS) as byproducts.
-The function of the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain (ETC) is to transfer electrons from carbon to oxygen and release energy in the form of ATP.

The #1 theory of how pulsed Magnetic Fields affect the ETC is by the RPM

The ETC consists of:
-Complex I – NADH dehydrogenase
-Complex II – Succinate dehydrogenase
-➡ Complex III – Cytochrome bc₁ complex
-Complex IV – Cytochrome c oxidase
-ATP synthase (often called Complex V)

Complex III sits between Coenzyme Q (ubiquinol) and cytochrome c.

Complex III is a major regulated source of mitochondrial ROS, especially:
-Superoxide generation at the Qo site
-ROS used for redox signaling (HIF stabilization, signaling adaptation)
-Excess ROS contributes to DNA damage and cell death


Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
4946- PEITC,    Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ETC↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 2,   selectivity↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ETC, Electron Transport Chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:1386  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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