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| Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M). Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division). |
| Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression. TP53 is the most commonly mutated gene in human cancer. HH↑, GLI-1↑, SHH↑ P53↓ The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca. It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma. Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer. It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress. Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC. |
| 6396- | ANE, | FEO, | Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis |
| - | in-vitro, | Pca, | PC3 |
| 1151- | Api, | Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | 22Rv1 | - | in-vivo, | NA, | NA |
| 1564- | Api, | Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation |
| - | in-vitro, | Pca, | 22Rv1 | - | in-vivo, | NA, | NA |
| 5171- | Ash, | The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry" |
| - | vitro+vivo, | Pca, | LNCaP | - | vitro+vivo, | Pca, | PC3 |
| 2603- | Ba, | Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 |
| 755- | Bor, | https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | PC, | PC3 |
| 720- | Bor, | High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line |
| - | in-vitro, | Pca, | DU145 |
| 5828- | CAP, | Capsaicin: a novel radio-sensitizing agent for prostate cancer |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 |
| 5761- | CAPE, | Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 |
| 5951- | Cela, | Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer |
| - | vitro+vivo, | Pca, | NA |
| 6316- | Cro, | Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | 22Rv1 |
| 154- | CUR, | Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts |
| - | vitro+vivo, | Pca, | PC3 |
| 141- | CUR, | Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer |
| - | in-vivo, | Pca, | PC3 |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | PC, | DU145 | - | in-vitro, | PC, | LNCaP |
| 152- | CUR, | Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer |
| - | in-vivo, | Pca, | NA |
| 126- | CUR, | Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells |
| - | in-vitro, | Pca, | 22Rv1 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 134- | CUR, | RES, | MEL, | SIL, | Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | PC3 |
| 129- | CUR, | Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation |
| - | vitro+vivo, | Pca, | LNCaP |
| 131- | CUR, | Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer |
| - | vitro+vivo, | Pca, | LNCaP | - | vitro+vivo, | Pca, | 22Rv1 |
| 164- | CUR, | Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro |
| - | in-vitro, | Pca, | PC3 |
| 6590- | DAS, | Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells |
| - | in-vitro, | Pca, | NA |
| 6669- | Deg, | Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells |
| - | vitro+vivo, | Pca, | NA |
| 2157- | dietP, | Plant-Based Diets and Disease Progression in Men With Prostate Cancer |
| - | Study, | Pca, | NA |
| 690- | EGCG, | Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer |
| - | in-vitro, | Pca, | NA |
| 2993- | EGCG, | Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells |
| - | in-vitro, | Pca, | LNCaP |
| 5226- | EMD, | Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells |
| - | vitro+vivo, | Pca, | MIA PaCa-2 |
| 6796- | EPA, | Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines |
| - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | Pca, | PANC1 |
| 6793- | EPA, | Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| 6898- | FIS, | Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | LNCaP |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 1958- | GamB, | Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells |
| - | in-vitro, | Pca, | NA | - | in-vivo, | NA, | NA |
| 825- | GAR, | Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | Bxpc-3 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | C4-2B |
| 29- | GEN, | Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway |
| - | in-vivo, | Pca, | 22Rv1 | - | in-vivo, | Pca, | DU145 |
| 7245- | Gink, | Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity |
| - | vitro+vivo, | Pca, | DU145 | - | in-vitro, | CRC, | HCT116 | - | in-vitro, | Nor, | MCF10 |
| 7258- | Gink, | Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity |
| - | vitro+vivo, | Pca, | DU145 | - | in-vitro, | CRC, | HCT116 |
| 7312- | Gos, | A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum |
| - | vitro+vivo, | Pca, | PC3 | - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 7309- | Gos, | Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa |
| - | vitro+vivo, | Pca, | PC3 |
| 7337- | Gra, | Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer |
| - | in-vitro, | Pca, | NA |
| 2407- | HCAs, | 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2 |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | LNCaP |
| 7608- | I3C, | Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells |
| - | in-vitro, | Pca, | PC3 |
| 7593- | I3C, | Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells |
| - | Review, | Pca, | NA |
| 7689- | iod, | Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines |
| - | in-vitro, | Nor, | RWPE-1 | - | in-vitro, | Pca, | LNCaP | - | vitro+vivo, | Pca, | DU145 |
| - | in-vivo, | Pca, | DU145 |
| 7712- | IP6, | Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice |
| - | in-vivo, | Pca, | NA |
| 7718- | IP6, | Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes |
| - | in-vitro, | Pca, | DU145 |
| 7723- | IP6, | Prostate cancer and inositol hexaphosphate: efficacy and mechanisms |
| - | Review, | Pca, | NA |
| 7725- | IP6, | Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| 7692- | IP6, | Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells |
| - | in-vitro, | Pca, | DU145 |
| 1293- | IP6, | Inositol Hexaphosphate Inhibits Growth and Induces G1 Arrest and Apoptotic Death of Androgen-Dependent Human Prostate Carcinoma LNCaP Cells |
| - | vitro+vivo, | Pca, | LNCaP |
| 8021- | IVM, | The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells |
| - | vitro+vivo, | AML, | HL-60 | - | NA, | lymphoma, | U937 | - | NA, | Pca, | DU145 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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