STAT3 Cancer Research Results

STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
4808- ASTX,    Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer
- in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, STAT3↓, Apoptosis↑, TumCMig↓, TumCI↓,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,
5653- BNL,    Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells
- in-vitro, Pca, PC3
ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,
5746- CA,    Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
152- CUR,    Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer
- in-vivo, Pca, NA
β-catenin/ZEB1↓, AR↓, STAT3↓, p‑Akt↓, Mcl-1↓, Bcl-xL↓, cl‑PARP↑, miR-21↓, miR-205↑, TumCG↓, TumCP↓, TumCI↓, angioG↓, TumMeta↓,
7448- CYN,    Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs
- in-vitro, Pca, DU145
GSH↓, STAT3↓, Bcl-2↓, survivin↓, cl‑PARP↑, ChemoSen↑,
7089- GAR,    Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, PC, NA
STAT3↓, TumCI↓, NF-kB↓, uPA↓, VEGF↓, MMP9↓,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7258- Gink,    Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116
STAT3↓, survivin↓, TumCCA↑, TumCG↓, Dose↝,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓, Warburg↓,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
5186- PEITC,    Phenethyl Isothiocyanate inhibits STAT3 activation in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
TumCP↓, TumCCA↑, STAT3↓, p‑JAK2↓, eff↓, TumCCA↑, AR↓, ROS↑,
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
82- QC,  ATG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓, TumCP↓, chemoPv↑, TumCMig↓,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, p‑STAT3↓, Src↓, AMPK↑, GlutMet↑, TCA↑, glut↓,

Showing Research Papers: 1 to 22 of 22

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 22

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IL7↓, 1,   IRF1↑, 1,   miR-134↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSR↓, 1,   ROS↑, 9,   ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MPT↑, 1,   mtDam↑, 1,   XIAP?, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 4,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PI3K/Akt↓, 2,   PKM2↓, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 3,   Apoptosis↑, 9,   BAD↓, 1,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 4,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 5,   Casp↑, 2,   Casp3↑, 4,   proCasp3↓, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   IAP1↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑MAPK↓, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   p27/CDKN1B↑, 2,   p38↓, 1,   p38↑, 1,   survivin↓, 6,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↓, 1,   cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-205↑, 1,   miR-21↓, 2,   tumCV↓, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   NKX3.1↑, 1,   cl‑PARP↑, 7,   proPARP↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   cycD1/CCND1↓, 9,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   Src↓, 1,   STAT3↓, 15,   p‑STAT3↓, 8,   TumCG↓, 5,  

Migration(tgid=13) ⓘ

FAK↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 9,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL6↓, 4,   JAK1↓, 2,   JAK2↓, 1,   p‑JAK2↓, 1,   NF-kB↓, 7,   ac‑p65↑, 1,   PSA↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 1,   Dose?, 1,   Dose↝, 2,   eff↓, 3,   eff↑, 3,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 5,   EGFR↓, 1,   IL6↓, 4,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 4,   Obesity↓, 1,   PRAS40↓, 1,   toxicity↓, 2,   TumVol↓, 2,   TumW↓, 2,  
Total Targets: 124

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,  
Total Targets: 2

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
4 Curcumin
2 Arctigenin
2 Ginger/6-Shogaol/Gingerol
2 Ginkgetin
2 HydroxyTyrosol
2 lambertianic acid
2 Quercetin
1 Astaxanthin
1 EGCG (Epigallocatechin Gallate)
1 borneol
1 Caffeic acid
1 methylseleninic acid
1 Cynaropicrin
1 Garcinol
1 Niclosamide (Niclocide)
1 Nimbolide
1 Phenethyl isothiocyanate
1 Ursolic acid
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:373  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page