HemoG Cancer Research Results

HemoG, Hemoglobin: Click to Expand ⟱
Source:
Type:
Hemoglobin (often abbreviated as "HemoG") is a protein in red blood cells responsible for transporting oxygen throughout the body. While hemoglobin itself is not directly linked to cancer, there are several important aspects of its relationship with cancer that are worth noting:
Many cancer patients experience anemia, which is a condition characterized by low levels of hemoglobin. This can be due to various factors, including the cancer itself, chemotherapy, or nutritional deficiencies.
Tumors often have regions of low oxygen (hypoxia) due to inadequate blood supply. Hypoxia can promote tumor progression, metastasis, and resistance to therapy. Hemoglobin's role in oxygen transport makes it a critical factor in the tumor microenvironment, as oxygen levels can influence cancer cell behavior.
Changes in hemoglobin levels or the presence of specific hemoglobin variants may serve as potential biomarkers for certain cancers.
Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
92- QC,    Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways
- vitro+vivo, Pca, HUVECs - vitro+vivo, Pca, PC3
VEGFR2↓, HemoG↓, Akt↓, mTOR↓, P70S6K↓, angioG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   P70S6K↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGFR2↓, 1,  

Clinical Biomarkers ⓘ

HemoG↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HemoG, Hemoglobin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:487  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page