lysoM Cancer Research Results

lysoM, Lysosome Membrane Integrity: Click to Expand ⟱

Source:

Type:

Cancer cells often exhibit altered metabolism and increased autophagy to support their rapid growth and survival. Lysosomes are central to these processes, and any compromise in their integrity can disrupt cellular homeostasis.
When lysosomal membranes become permeable, it can lead to the release of cathepsins (lysosomal proteases) into the cytoplasm, which can trigger apoptosis or necrosis.

Loss of lysosomal membrane integrity is often associated with poor prognosis in various cancers. It can lead to increased cell survival, resistance to apoptosis, and enhanced tumor growth.

Protumorigenic: Disruption of lysosomal membrane integrity is generally considered protumorigenic. It can lead to the release of cathepsins and other hydrolytic enzymes that promote tumor cell invasion, migration, and metastasis. Additionally, it can contribute to the development of a pro-inflammatory tumor microenvironment.
Antitumorigenic: In some contexts, maintaining lysosomal integrity may support autophagic processes that can prevent tumorigenesis by degrading damaged organelles and proteins. However, this protective role is often compromised in cancer.

Pca, Prostate Cancer: Click to Expand ⟱

Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.

Scientific Papers found: Click to Expand⟱

318-

AgNPs,

Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells

in-vitro,

Pca,

PC3

lysoM↓, lysosome↓, AMPKα↑, TumAuto↑, mTOR↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,

Autophagy & Lysosomes ⓘ

lysoM↓, 1, lysosome↓, 1, TumAuto↑, 1,

Proliferation, Differentiation & Cell State ⓘ

mTOR↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: lysoM, Lysosome Membrane Integrity

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells