TRAF2 Cancer Research Results

TRAF2, TNF Receptor Associated Factor 2: Click to Expand ⟱
Source:
Type:

TRAF2 - TNF Receptor Associated Factor 2

Type: Signaling adaptor / E3 ubiquitin ligase-associated protein

Function: TRAF2 is a signaling adaptor recruited by multiple TNF receptor superfamily members and forms complexes with proteins including cIAP1/BIRC2, cIAP2/BIRC3, RIPK1, and other signaling regulators. It controls NF-κB, JNK/MAPK, inflammatory, survival, apoptotic, and immune-signaling pathways through ubiquitination-dependent signaling complexes.

Cancer: ↑ Frequently increased or functionally overactive in cancer. TRAF2 can promote NF-κB and MAPK signaling, tumor-cell survival, proliferation, inflammation, resistance to apoptosis, and treatment resistance. Amplification or increased TRAF2 signaling has been reported in several malignancies, although its effects depend on receptor and downstream signaling context.
Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
7628- Ins,    Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line
- in-vitro, Pca, DU145
tumCV↓, annexin II↓, Cofilin↓, Rho↑, APAF1↑, TRAF2↑, Apoptosis↑, PI3K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TRAF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   Cofilin↓, 1,   Rho↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRAF2, TNF Receptor Associated Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:1673  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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